1yis

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<StructureSection load='1yis' size='340' side='right'caption='[[1yis]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='1yis' size='340' side='right'caption='[[1yis]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1yis]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YIS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1yis]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YIS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c3c|1c3c]], [[1c3u|1c3u]], [[1dof|1dof]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenylosuccinate_lyase Adenylosuccinate lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.2.2 4.3.2.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yis OCA], [https://pdbe.org/1yis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yis RCSB], [https://www.ebi.ac.uk/pdbsum/1yis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yis ProSAT], [https://www.topsan.org/Proteins/SECSG/1yis TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yis OCA], [https://pdbe.org/1yis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yis RCSB], [https://www.ebi.ac.uk/pdbsum/1yis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yis ProSAT], [https://www.topsan.org/Proteins/SECSG/1yis TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PUR8_CAEEL PUR8_CAEEL]] Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
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[https://www.uniprot.org/uniprot/PUR8_CAEEL PUR8_CAEEL] Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adenylosuccinate lyase]]
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[[Category: Caenorhabditis elegans]]
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[[Category: Caeel]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: An, J]]
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[[Category: An J]]
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[[Category: Arabshahi, A]]
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[[Category: Arabshahi A]]
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[[Category: Bray, T]]
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[[Category: Bray T]]
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[[Category: Cao, Z]]
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[[Category: Cao Z]]
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[[Category: Chen, Y J]]
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[[Category: Chen Y-J]]
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[[Category: Delucas, L]]
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[[Category: Delucas L]]
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[[Category: Gray, R]]
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[[Category: Gray R]]
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[[Category: Huang, W]]
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[[Category: Huang W]]
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[[Category: Johnson, D]]
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[[Category: Johnson D]]
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[[Category: Karpova, E]]
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[[Category: Karpova E]]
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[[Category: Li, S]]
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[[Category: Li S]]
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[[Category: Lu, S]]
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[[Category: Lu S]]
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[[Category: Luan, C H]]
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[[Category: Luan C-H]]
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[[Category: Luo, D]]
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[[Category: Luo D]]
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[[Category: Luo, M]]
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[[Category: Luo M]]
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[[Category: McKinstry, A]]
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[[Category: McKinstry A]]
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[[Category: Qiu, S]]
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[[Category: Qiu S]]
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[[Category: Structural genomic]]
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[[Category: Schormann N]]
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[[Category: Schormann, N]]
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[[Category: Shang Q]]
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[[Category: Shang, Q]]
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[[Category: Symersky J]]
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[[Category: Symersky, J]]
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[[Category: Tsao J]]
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[[Category: Tsao, J]]
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[[Category: Zhang Y]]
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[[Category: Zhang, Y]]
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[[Category: Zhou J]]
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[[Category: Zhou, J]]
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[[Category: Caenorhabditis]]
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[[Category: Lyase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Secsg]]
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[[Category: X-ray structure]]
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Revision as of 08:03, 15 May 2024

Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase

PDB ID 1yis

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