1yxw
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1yxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YXW FirstGlance]. <br> | <table><tr><td colspan='2'>[[1yxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YXW FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yxw OCA], [https://pdbe.org/1yxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yxw RCSB], [https://www.ebi.ac.uk/pdbsum/1yxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yxw ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yxw OCA], [https://pdbe.org/1yxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yxw RCSB], [https://www.ebi.ac.uk/pdbsum/1yxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yxw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Clostridium tetani]] | [[Category: Clostridium tetani]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Eswaramoorthy S]] | |
| - | [[Category: Eswaramoorthy | + | [[Category: Jayaraman S]] |
| - | [[Category: Jayaraman | + | [[Category: Kumaran D]] |
| - | [[Category: Kumaran | + | [[Category: Swaminathan S]] |
| - | [[Category: Swaminathan | + | |
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Current revision
A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin
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