2wq8

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<StructureSection load='2wq8' size='340' side='right'caption='[[2wq8]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='2wq8' size='340' side='right'caption='[[2wq8]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusairum_graminearum Fusairum graminearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQ8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_graminearum Fusarium graminearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQ8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jkx|2jkx]], [[2vz3|2vz3]], [[1gof|1gof]], [[1k3i|1k3i]], [[1t2x|1t2x]], [[1goh|1goh]], [[2vz1|2vz1]], [[1gog|1gog]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Galactose_oxidase Galactose oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.9 1.1.3.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wq8 OCA], [https://pdbe.org/2wq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wq8 RCSB], [https://www.ebi.ac.uk/pdbsum/2wq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wq8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wq8 OCA], [https://pdbe.org/2wq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wq8 RCSB], [https://www.ebi.ac.uk/pdbsum/2wq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wq8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GAOA_GIBZE GAOA_GIBZE]] Catalyzes the sterospecific oxidation of primary alcohols to the corresponding aldehydes. The biologically relevant substrate of the enzyme is not known as the enzyme exhibits broad substrate specificity from small alcohols through sugars to oligo- and polysaccharides (By similarity).
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[https://www.uniprot.org/uniprot/GAOA_GIBZA GAOA_GIBZA] Catalyzes the sterospecific oxidation of primary alcohols to the corresponding aldehydes. The biologically relevant substrate of the enzyme is not known as the enzyme exhibits broad substrate specificity from small alcohols through sugars to oligo- and polysaccharides.<ref>PMID:13641238</ref> <ref>PMID:4441089</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fusairum graminearum]]
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[[Category: Fusarium graminearum]]
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[[Category: Galactose oxidase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Behrens, C]]
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[[Category: Behrens C]]
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[[Category: Flitsch, S L]]
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[[Category: Flitsch SL]]
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[[Category: Grogan, G J]]
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[[Category: Grogan GJ]]
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[[Category: Ioannou, A]]
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[[Category: Ioannou A]]
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[[Category: Rannes, J G]]
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[[Category: Rannes JG]]
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[[Category: Turner, N J]]
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[[Category: Turner NJ]]
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[[Category: Willies, S C]]
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[[Category: Willies SC]]
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[[Category: Directed evolution]]
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[[Category: Glycoengineering]]
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[[Category: Kelch repeat]]
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[[Category: Metal-binding]]
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[[Category: Oxidoreductase]]
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Revision as of 10:13, 20 December 2023

Glycan labelling using engineered variants of galactose oxidase obtained by directed evolution

PDB ID 2wq8

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