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2wzo

From Proteopedia

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Current revision (10:19, 9 May 2024) (edit) (undo)
 
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<StructureSection load='2wzo' size='340' side='right'caption='[[2wzo]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='2wzo' size='340' side='right'caption='[[2wzo]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wzo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wzo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzo OCA], [https://pdbe.org/2wzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wzo RCSB], [https://www.ebi.ac.uk/pdbsum/2wzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzo OCA], [https://pdbe.org/2wzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wzo RCSB], [https://www.ebi.ac.uk/pdbsum/2wzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TBRG1_HUMAN TBRG1_HUMAN]] Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.<ref>PMID:17110379</ref>
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[https://www.uniprot.org/uniprot/TBRG1_HUMAN TBRG1_HUMAN] Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.<ref>PMID:17110379</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Allen, M D]]
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[[Category: Allen MD]]
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[[Category: Bycroft, M]]
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[[Category: Bycroft M]]
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[[Category: Garcia-Alai, M M]]
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[[Category: Garcia-Alai MM]]
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[[Category: Joerger, A C]]
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[[Category: Joerger AC]]
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[[Category: Cell cycle]]
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[[Category: Nucleus]]
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[[Category: Tumor suppressor]]
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Current revision

The structure of the FYR domain

PDB ID 2wzo

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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