1fms

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{{STRUCTURE_1fms| PDB=1fms | SCENE= }}
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'''Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)'''
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===Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)===
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==Overview==
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2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
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(as it appears on PubMed at http://www.pubmed.gov), where 11128631 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11128631}}
==About this Structure==
==About this Structure==
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[[Category: Simpson, I J.]]
[[Category: Simpson, I J.]]
[[Category: Dna-drug minor groove complex]]
[[Category: Dna-drug minor groove complex]]
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Revision as of 00:31, 1 July 2008

Image:1fms.png

Template:STRUCTURE 1fms

Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)

Template:ABSTRACT PUBMED 11128631

About this Structure

Full crystallographic information is available from OCA.

Reference

DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631

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