Monoclonal Antibodies 3D structures

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Line 8: Line 8:
*Human Fab
*Human Fab
-
**[[3n9g]], [[3giz]], [[3eo9]], [[1ad9]], [[2fb4]], [[2ig2]], [[1qlr]], [[2zkh]], [[1qbl]], [[1igi]], [[5nst]], [[6amj]], [[6cr1]], [[6h9x]], [[6rco]], [[6rcq]], [[6rcs]], [[6tcm]], [[6tcn]], [[6umh]], [[6umi]], [[6umj]] – hFab mAb - human<br />
+
**[[3n9g]], [[3giz]], [[3eo9]], [[1ad9]], [[2fb4]], [[2ig2]], [[1qlr]], [[2zkh]], [[1qbl]], [[1igi]], [[5nst]], [[6amj]], [[6cr1]], [[6h9x]], [[6rco]], [[6rcq]], [[6rcs]], [[6tcm]], [[6tcn]], [[6umh]], [[6umi]], [[6umj]] – hFab - human<br />
**[[6amm]], [[6anp]], [[6ao0]], [[6tcp]], [[6tcq]] – hFab (mutant)<br />
**[[6amm]], [[6anp]], [[6ao0]], [[6tcp]], [[6tcq]] – hFab (mutant)<br />
-
**[[3qhz]], [[4fql]], [[4gxv]], [[6btj]] - hFab anti-influenza<br />
 
-
**[[3qhf]] – hFab anti-influenza (mutant)<br />
 
**[[3qct]] – hFab anti-lysophosphatidic acid<br />
**[[3qct]] – hFab anti-lysophosphatidic acid<br />
-
**[[3inu]], [[6n7u]] – hFab anti-Ebola<br />
 
**[[5jrp]] – hFab anti-Marburg virus<br />
**[[5jrp]] – hFab anti-Marburg virus<br />
**[[3u6r]], [[1nlb]], [[6meg]], [[6med]], [[6mee]], [[6mef]], [[6wo5]], [[6x9x]] - hFab anti-hepatitis C virus<br />
**[[3u6r]], [[1nlb]], [[6meg]], [[6med]], [[6mee]], [[6mef]], [[6wo5]], [[6x9x]] - hFab anti-hepatitis C virus<br />
Line 32: Line 29:
**[[4g5z]] – hFab canakinumab<br />
**[[4g5z]] – hFab canakinumab<br />
**[[1fh5]] – hFab Mak33<br />
**[[1fh5]] – hFab Mak33<br />
-
**[[3hmw]] - hFab ustekinumab <br />
 
**[[3hmw]] - hFab ustekinumab <br />
**[[3hmw]] - hFab ustekinumab <br />
**[[4k7p]] – hFab rhumab6 + mFab 10C4<br />
**[[4k7p]] – hFab rhumab6 + mFab 10C4<br />
Line 93: Line 89:
**[[6fbj]] - mFab anti-matrix melalloproteinase<br />
**[[6fbj]] - mFab anti-matrix melalloproteinase<br />
**[[6gxx]], [[6i1o]], [[6qu9]] - mFab anti-antitrypsin<br />
**[[6gxx]], [[6i1o]], [[6qu9]] - mFab anti-antitrypsin<br />
-
**[[6dg2]] – mFab anti-Ebola<br />
 
**[[6lkt]], [[6ltg]] – mFab anti-herpesvirus<br />
**[[6lkt]], [[6ltg]] – mFab anti-herpesvirus<br />
**[[6d9g]] – mFab anti-serotonin transporter<br />
**[[6d9g]] – mFab anti-serotonin transporter<br />
Line 106: Line 101:
**[[6nc3]], [[6nc2]] – hFab anti-HIV + glycoprotein gp120 + glycoprotein gp41 – Cryo EM<br />
**[[6nc3]], [[6nc2]] – hFab anti-HIV + glycoprotein gp120 + glycoprotein gp41 – Cryo EM<br />
**[[3w9e]] – hFab anti-HIV 2 + glycoprotein D <br />
**[[3w9e]] – hFab anti-HIV 2 + glycoprotein D <br />
-
**[[7kde]] – hFab anti-HIV + HIV protein – Cryo EM<br />
+
**[[7kde]], [[7l86]], [[7l87]], [[7l88]], [[7l89]], [[7l8a]], [[7l8b]], [[7l8c]], [[7l8d]], [[7l8s]], [[7l8t]], [[7l8w]], [[7l8x]], [[7l8y]], [[7l8z]], [[7l90]] – hFab + HIV protein – Cryo EM<br />
 +
**[[3idg]], [[3idi]], [[3idj]], [[3idm]], [[3idn]], [[3d0v]], [[2pw1]], [[2pw2]], [[3lex]], [[3ley]], [[6x58]] – hFab anti-HIV + gp41 peptide<br />
 +
**[[3mnz]] - hmFab anti-HIV + gp41 peptide<br />
 +
**[[2qsc]] - hFab anti-HIV + envelope glycoprotein peptide<br />
 +
**[[3uji]] - hFab anti-HIV + envelope glycoprotein gp160 peptide<br />
 +
**[[3mlr]], [[3mls]], [[3mlt]], [[3mlu]], [[3mlv]], [[3mlw]], [[3mlx]], [[3mly]], [[3mlz]] – hFab 2557 anti-HIV + V3 peptide<br />
 +
**[[1q1j]], [[3ujj]], [[4xmk]], [[6db5]], [[6db6]], [[6db7]] - hFab anti-HIV + glycoprotein gp120 peptide<br />
 +
**[[2hrp]] - hFab anti-HIV + HIV-1 protease peptide<br />
 +
**[[4zto]] - rFab anti-HIV R53 + glycoprotein gp120 peptide<br />
**[[3cle]], [[3clf]], [[3cmo]], [[1h3p]], [[3oz9]], [[1mf2]], [[1nld]], [[1bog]], [[3mnv]], [[1il1]], [[7kkz]] - mFab anti-HIV<br />
**[[3cle]], [[3clf]], [[3cmo]], [[1h3p]], [[3oz9]], [[1mf2]], [[1nld]], [[1bog]], [[3mnv]], [[1il1]], [[7kkz]] - mFab anti-HIV<br />
**[[1rzk]] – mFab anti-HIV + glycoprotein gp120 <br />
**[[1rzk]] – mFab anti-HIV + glycoprotein gp120 <br />
Line 114: Line 117:
**[[6did]] – rFab anti-HIV 10A + glycoprotein gp160 <br />
**[[6did]] – rFab anti-HIV 10A + glycoprotein gp160 <br />
**[[6p62]] – rFab anti-HIV E70 + env NFL – Cryo EM<br />
**[[6p62]] – rFab anti-HIV E70 + env NFL – Cryo EM<br />
 +
 +
*Anti-influenza virus Fab
 +
 +
**[[3qhz]], [[4fql]], [[4gxv]], [[6btj]] - hFab anti-influenza<br />
 +
**[[3qhf]] – hFab anti-influenza (mutant)<br />
 +
**[[4n8c]] – mFab + influenza peptide<br />
 +
**[[4ubd]], [[5vag]], [[6mlm]], [[6p3r]], [[6p3s]], [[6pdx]], [[6uig]] – hFab + influenza virus hemagglutinin<br />
 +
**[[7mem]] – hFab + influenza virus hemagglutinin – Cryo EM<br />
 +
**[[6lxi]], [[6lxj]], [[6lxk]] – hFab + influenza virus neuraminidase<br />
 +
**[[4lvh]], [[1qfu]] – mFab anti-influenza haemagglutinin<br />
 +
**[[2aep]], [[2aeq]], [[1nma]], [[1nmb]], [[1nmc]] – mFab + influenza virus neuraminidase<br />
 +
**[[6j9o]] – hscFv anti-influenza<br />
 +
 +
*Anti-Ebola virus Fab
 +
 +
**[[3inu]], [[6n7u]] – hFab anti-Ebola<br />
 +
**[[6dg2]] – mFab anti-Ebola<br />
 +
**[[6n7j]] - hFab anti-ebola + ebola peptide<br />
 +
**[[2qhr]] – mFab + Ebola envelope glycoprotein peptide<br />
 +
**[[6pci]], [[6dzm]], [[6uye]] – hFab + ebola spike proteins – Cryo EM<br />
 +
**[[6oz9]] – hFab + ebola glycoprotein<br />
* Other Fab
* Other Fab
Line 120: Line 144:
**[[6l8t]] - hmFab anti-hepatitis B<br />
**[[6l8t]] - hmFab anti-hepatitis B<br />
**[[2hwz]] – hmFab MEDI-493<br />
**[[2hwz]] – hmFab MEDI-493<br />
-
**[[6e64]] – raFab anti-malaria<br />
+
**[[6e64]] – rFab anti-malaria<br />
**[[4idl]] – LgFab anti-cholera toxin<br />
**[[4idl]] – LgFab anti-cholera toxin<br />
**[[1c5d]], [[1fn4]] – Fab anti-acetylcholine receptor - rat<br />
**[[1c5d]], [[1fn4]] – Fab anti-acetylcholine receptor - rat<br />
Line 164: Line 188:
**[[7c94]] – hFab + podoplanin peptide<br />
**[[7c94]] – hFab + podoplanin peptide<br />
**[[6b5l]], [[6b5m]], [[6b5n]], [[6b5o]], [[6b5p]], [[6b5r]], [[6b5s]], [[6b5t]], [[6pbv]], [[6pbw]] – hFab + CSP peptide<br />
**[[6b5l]], [[6b5m]], [[6b5n]], [[6b5o]], [[6b5p]], [[6b5r]], [[6b5s]], [[6b5t]], [[6pbv]], [[6pbw]] – hFab + CSP peptide<br />
-
**[[6n7j]] - hFab anti-ebola + ebola peptide<br />
 
**[[2osl]] – hmFab + CD20 peptide<br />
**[[2osl]] – hmFab + CD20 peptide<br />
**[[3o41]], [[3o45]] – mFab + fusion protein F1 peptide<br />
**[[3o41]], [[3o45]] – mFab + fusion protein F1 peptide<br />
Line 174: Line 197:
**[[2zpk]] – mFab + proteinase-activated receptor peptide<br />
**[[2zpk]] – mFab + proteinase-activated receptor peptide<br />
**[[3bae]], [[3bkj]], [[2r0w]], [[2r0z]], [[2ipu]] - mFab + amyloid peptide<br />
**[[3bae]], [[3bkj]], [[2r0w]], [[2r0z]], [[2ipu]] - mFab + amyloid peptide<br />
-
**[[2qhr]] – mFab + Ebola envelope glycoprotein peptide<br />
 
**[[1ejo]] - mFab + foot-and-mouth virus peptide<br />
**[[1ejo]] - mFab + foot-and-mouth virus peptide<br />
**[[2a6d]], [[2a6i]], [[2a6j]], [[2a6k]] – mFab 36-65 + peptide<br />
**[[2a6d]], [[2a6i]], [[2a6j]], [[2a6k]] – mFab 36-65 + peptide<br />
Line 189: Line 211:
**[[2or9]] - mFab anti-C-myc + peptide<br />
**[[2or9]] - mFab anti-C-myc + peptide<br />
**[[4tul]], [[4tuk]], [[4tuj]] – mFab anti-neuroblastoma + peptide<br />
**[[4tul]], [[4tuk]], [[4tuj]] – mFab anti-neuroblastoma + peptide<br />
-
**[[4n8c]] – mFab + influenza peptide<br />
 
**[[4bh8]], [[4bh7]] – mFab anti-ARS murine germline + peptide<br />
**[[4bh8]], [[4bh7]] – mFab anti-ARS murine germline + peptide<br />
**[[6sf6]] – mFab + COMP peptide<br />
**[[6sf6]] – mFab + COMP peptide<br />
**[[7doh]] – mFab + rhodopsin peptide<br />
**[[7doh]] – mFab + rhodopsin peptide<br />
**[[6uud]], [[6x87]], [[6x8p]], [[6x8q]], [[6x8s]], [[6x8u]] – mFab + CSP peptide<br />
**[[6uud]], [[6x87]], [[6x8p]], [[6x8q]], [[6x8s]], [[6x8u]] – mFab + CSP peptide<br />
-
**[[6lz4]] – raFab + MAP peptide<br />
+
**[[6lz4]] – rFab + MAP peptide<br />
-
 
+
-
*Anti-HIV Fab: peptide complex
+
-
 
+
-
**[[3idg]], [[3idi]], [[3idj]], [[3idm]], [[3idn]], [[3d0v]], [[2pw1]], [[2pw2]], [[3lex]], [[3ley]], [[6x58]] – hFab anti-HIV + gp41 peptide<br />
+
-
**[[3mnz]] - hmFab anti-HIV + gp41 peptide<br />
+
-
**[[2qsc]] - hFab anti-HIV + envelope glycoprotein peptide<br />
+
-
**[[3uji]] - hFab anti-HIV + envelope glycoprotein gp160 peptide<br />
+
-
**[[3mlr]], [[3mls]], [[3mlt]], [[3mlu]], [[3mlv]], [[3mlw]], [[3mlx]], [[3mly]], [[3mlz]] – hFab 2557 anti-HIV + V3 peptide<br />
+
-
**[[1q1j]], [[3ujj]], [[4xmk]], [[6db5]], [[6db6]], [[6db7]] - hFab anti-HIV + glycoprotein gp120 peptide<br />
+
-
**[[2hrp]] - hFab anti-HIV + HIV-1 protease peptide<br />
+
-
**[[4zto]] - rFab anti-HIV R53 + glycoprotein gp120 peptide<br />
+
*Anti-SARS-CoV Fab
*Anti-SARS-CoV Fab
Line 278: Line 288:
**[[6iw0]], [[6iw2]], [[6ivz]] – hFab + yellow fever E protein <br />
**[[6iw0]], [[6iw2]], [[6ivz]] – hFab + yellow fever E protein <br />
**[[3iyw]] – hFab mAb + West Nile virus surface protein<br />
**[[3iyw]] – hFab mAb + West Nile virus surface protein<br />
-
**[[4ubd]], [[5vag]], [[6mlm]], [[6p3r]], [[6p3s]], [[6pdx]], [[6uig]] – hFab + influenza virus hemagglutinin<br />
 
-
**[[7mem]] – hFab + influenza virus hemagglutinin – Cryo EM<br />
 
-
**[[6lxi]], [[6lxj]], [[6lxk]] – hFab + influenza virus neuraminidase<br />
 
**[[7dwt]], [[7dwu]] – hFab + Dengue envelope glycoprotein – Cryo EM<br />
**[[7dwt]], [[7dwu]] – hFab + Dengue envelope glycoprotein – Cryo EM<br />
**[[6weq]], [[6wer]] – hFab + dengue virus NS1c <br />
**[[6weq]], [[6wer]] – hFab + dengue virus NS1c <br />
Line 292: Line 299:
**[[6dfi]], [[6dfj]], [[6jep]], [[6jfh]], [[6jfi]], [[7bpk]] – hFab + zika protein <br />
**[[6dfi]], [[6dfj]], [[6jep]], [[6jfh]], [[6jfi]], [[7bpk]] – hFab + zika protein <br />
**[[6uoe]] – hFab + herpesvirus protein<br />
**[[6uoe]] – hFab + herpesvirus protein<br />
-
**[[6pci]], [[6dzm]], [[6uye]] – hFab + ebola spike proteins – Cryo EM<br />
 
-
**[[6oz9]] – hFab + ebola glycoprotein<br />
 
**[[7cn2]] – hFab + papilloma virus capsid – Cryo EM<br />
**[[7cn2]] – hFab + papilloma virus capsid – Cryo EM<br />
-
**[[7l86]], [[7l87]], [[7l88]], [[7l89]], [[7l8a]], [[7l8b]], [[7l8c]], [[7l8d]], [[7l8s]], [[7l8t]], [[7l8w]], [[7l8x]], [[7l8y]], [[7l8z]], [[7l90]] – hFab + HIV protein – Cryo EM<br />
 
**[[6wm9]], [[6wn1]], [[6wno]], [[6woz]], [[6wqo]], [[6wtu]], [[6wtv]], [[6wty]] - hFab + reticulocyte binding protein<br />
**[[6wm9]], [[6wn1]], [[6wno]], [[6woz]], [[6wqo]], [[6wtu]], [[6wtv]], [[6wty]] - hFab + reticulocyte binding protein<br />
**[[6ous]], [[7mmn]] – hFab + HRSV protein<br />
**[[6ous]], [[7mmn]] – hFab + HRSV protein<br />
Line 355: Line 359:
*Mouse Fab: viral protein complex
*Mouse Fab: viral protein complex
-
**[[4lvh]], [[1qfu]] – mFab anti-influenza haemagglutinin<br />
 
-
**[[2aep]], [[2aeq]], [[1nma]], [[1nmb]], [[1nmc]] – mFab + influenza virus neuraminidase<br />
 
**[[3i50]], [[1ztx]] – mFab E53 + West Nile virus envelope glycoprotein<br />
**[[3i50]], [[1ztx]] – mFab E53 + West Nile virus envelope glycoprotein<br />
**[[2r29]], [[4l5f]] – mFab + Dengue envelope glycoprotein<br />
**[[2r29]], [[4l5f]] – mFab + Dengue envelope glycoprotein<br />
Line 362: Line 364:
**[[3j1s]], [[6ewb]] – mFab + Vp1<br />
**[[3j1s]], [[6ewb]] – mFab + Vp1<br />
**[[2xqy]] - mFab anti-pseudorabies virus + glycoprotein H <br />
**[[2xqy]] - mFab anti-pseudorabies virus + glycoprotein H <br />
-
**[[3bgf]], [[4f2m]] – mFab + SARS spike protein<br />
 
**[[3v7a]] - mFab + norovirus capsid protein<br />
**[[3v7a]] - mFab + norovirus capsid protein<br />
**[[6l62]] - mFab + circovirus capsid protein – Cryo EM<br />
**[[6l62]] - mFab + circovirus capsid protein – Cryo EM<br />
Line 383: Line 384:
**[[1bj1]], [[2vwe]] - hmFab + VEGF<br />
**[[1bj1]], [[2vwe]] - hmFab + VEGF<br />
**[[3uaj]], [[3uc0]] – Fab + envelope protein - chimpanzee<br />
**[[3uaj]], [[3uc0]] – Fab + envelope protein - chimpanzee<br />
-
**[[3b9k]] – rFab + CD8<br />
+
**[[3b9k]] – raFab + CD8<br />
-
**[[6i9i]] – rFab + Rift Valley fever virus glycoprotein<br />
+
**[[6i9i]] – raFab + Rift Valley fever virus glycoprotein<br />
-
**[[6t3f]] – rFab + Nipah virus glycoprotein<br />
+
**[[6t3f]] – raFab + Nipah virus glycoprotein<br />
-
**[[6osh]], [[6osn]], [[6osv]] – rFab + ROR2<br />
+
**[[6osh]], [[6osn]], [[6osv]] – raFab + ROR2<br />
-
**[[6e62]] – rFab + Pf48/45<br />
+
**[[6e62]] – raFab + Pf48/45<br />
-
**[[6h5n]] – raFab + malaria protein<br />
+
**[[6h5n]] – rFab + malaria protein<br />
-
**[[6zvf]] – raFab + galectin<br />
+
**[[6zvf]] – rFab + galectin<br />
-
**[[6icc]], [[6icf]] – raFab + S2P<br />
+
**[[6icc]], [[6icf]] – rFab + S2P<br />
-
**[[7o9s]] - raFab + hantavirus envelope polyprotein <br />
+
**[[7o9s]] - rFab + hantavirus envelope polyprotein <br />
-
**[[7nks]], [[7nrh]] - raFab + hantavirus envelope polyprotein <br />
+
**[[7nks]], [[7nrh]] - rFab + hantavirus envelope polyprotein <br />
**[[6z06]] - vFab + hantavirus envelope polyprotein – vole<br />
**[[6z06]] - vFab + hantavirus envelope polyprotein – vole<br />
**[[7b09]] - vFab + hantavirus envelope polyprotein - Cryo EM<br />
**[[7b09]] - vFab + hantavirus envelope polyprotein - Cryo EM<br />
Line 477: Line 478:
**[[6ehy]], [[6ehx]], [[6ehw]], [[6ehv]], [[5j75]], [[5j74]], [[5c2b]], [[2a9n]], [[2a9m]], [[6tcs]] – hscFv<br />
**[[6ehy]], [[6ehx]], [[6ehw]], [[6ehv]], [[5j75]], [[5j74]], [[5c2b]], [[2a9n]], [[2a9m]], [[6tcs]] – hscFv<br />
**[[6tco]], [[6tcr]] – hscFv (mutant)<br />
**[[6tco]], [[6tcr]] – hscFv (mutant)<br />
-
**[[6j9o]] – hscFv anti-influenza<br />
 
**[[5wn9]], [[4kv5]] – hscFv + peptide<br />
**[[5wn9]], [[4kv5]] – hscFv + peptide<br />
**[[1n4x]], [[1moe]], [[5vf2]], [[5i4f]], [[5b3n]], [[4nko]], [[4nkm]], [[4nkd]], [[4h0i]], [[4h0g]], [[4gqp]], [[3umt]], [[3nn8]] – mscFv<br />
**[[1n4x]], [[1moe]], [[5vf2]], [[5i4f]], [[5b3n]], [[4nko]], [[4nkm]], [[4nkd]], [[4h0i]], [[4h0g]], [[4gqp]], [[3umt]], [[3nn8]] – mscFv<br />

Revision as of 09:02, 9 November 2021

3D structures of Monoclonal Antibody

Updated on 09-November-2021

Humanized mouse antibody (hmFab) is a modified mFab which resembles more hFab.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman

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