1fnf

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{{STRUCTURE_1fnf| PDB=1fnf | SCENE= }}
{{STRUCTURE_1fnf| PDB=1fnf | SCENE= }}
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'''FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10'''
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===FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10===
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==Overview==
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We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.
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(as it appears on PubMed at http://www.pubmed.gov), where 8548820 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8548820}}
==About this Structure==
==About this Structure==
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[[Category: Extracellular matrix]]
[[Category: Extracellular matrix]]
[[Category: Rgd]]
[[Category: Rgd]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:32:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:37:04 2008''

Revision as of 00:37, 1 July 2008

Image:1fnf.png

Template:STRUCTURE 1fnf

FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10

Template:ABSTRACT PUBMED 8548820

About this Structure

1FNF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region., Leahy DJ, Aukhil I, Erickson HP, Cell. 1996 Jan 12;84(1):155-64. PMID:8548820

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