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1fnn

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{{STRUCTURE_1fnn| PDB=1fnn | SCENE= }}
{{STRUCTURE_1fnn| PDB=1fnn | SCENE= }}
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'''CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM'''
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===CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM===
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==Overview==
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Cdc6/Cdc18 is a conserved and essential component of prereplication complexes. The 2.0 A crystal structure of an archaeal Cdc6 ortholog, in conjunction with a mutational analysis of the homologous Cdc18 protein from Schizosaccharomyces pombe, reveals novel aspects of Cdc6/Cdc18 function. Two domains of Cdc6 form an AAA+-type nucleotide binding fold that is observed bound to Mg.ADP. A third domain adopts a winged-helix fold similar to known DNA binding modules. Sequence comparisons show that the winged-helix domain is conserved in Orc1, and mutagenesis data demonstrate that this region of Cdc6/Cdc18 is required for function in vivo. Additional mutational analyses suggest that nucleotide binding and/or hydrolysis by Cdc6/Cdc18 is required not only for progression through S phase, but also for maintenance of checkpoint control during S phase.
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(as it appears on PubMed at http://www.pubmed.gov), where 11030343 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11030343}}
==About this Structure==
==About this Structure==
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[[Category: Dna replication initation factor]]
[[Category: Dna replication initation factor]]
[[Category: Orc1]]
[[Category: Orc1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:32:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:37:51 2008''

Revision as of 00:37, 1 July 2008

Image:1fnn.png

Template:STRUCTURE 1fnn

CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM

Template:ABSTRACT PUBMED 11030343

About this Structure

1FNN is a Single protein structure of sequence from Pyrobaculum aerophilum. Full crystallographic information is available from OCA.

Reference

Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control., Liu J, Smith CL, DeRyckere D, DeAngelis K, Martin GS, Berger JM, Mol Cell. 2000 Sep;6(3):637-48. PMID:11030343

Page seeded by OCA on Tue Jul 1 03:37:51 2008

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