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2yym

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Current revision (09:12, 25 October 2023) (edit) (undo)
 
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<StructureSection load='2yym' size='340' side='right'caption='[[2yym]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2yym' size='340' side='right'caption='[[2yym]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yym]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YYM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yym]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YYM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HP:4-HYDROXYPHENYLACETATE'>4HP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yyg|2yyg]], [[2yyi|2yyi]], [[2yyj|2yyj]], [[2yyk|2yyk]], [[2yyl|2yyl]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HP:4-HYDROXYPHENYLACETATE'>4HP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-hydroxyphenylacetate_3-monooxygenase 4-hydroxyphenylacetate 3-monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.9 1.14.14.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yym OCA], [https://pdbe.org/2yym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yym RCSB], [https://www.ebi.ac.uk/pdbsum/2yym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yym ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yym OCA], [https://pdbe.org/2yym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yym RCSB], [https://www.ebi.ac.uk/pdbsum/2yym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yym ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HPAB_THET8 HPAB_THET8]] Utilizes FADH(2) supplied by HpaC, to catalyze the hydroxylation of 4-hydroxyphenylacetic acid, leading to the production of 3,4-dihydroxyphenylacetic acid (DHPA).<ref>PMID:17804419</ref>
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[https://www.uniprot.org/uniprot/HPAB_THET8 HPAB_THET8] Utilizes FADH(2) supplied by HpaC, to catalyze the hydroxylation of 4-hydroxyphenylacetic acid, leading to the production of 3,4-dihydroxyphenylacetic acid (DHPA).<ref>PMID:17804419</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 4-hydroxyphenylacetate 3-monooxygenase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thet8]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Ebihara, A]]
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[[Category: Ebihara A]]
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[[Category: Hisano, T]]
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[[Category: Hisano T]]
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[[Category: Iwasaki, W]]
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[[Category: Iwasaki W]]
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[[Category: Kim, S H]]
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[[Category: Kim S-H]]
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[[Category: Miki, K]]
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[[Category: Miki K]]
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[[Category: Takeda, K]]
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[[Category: Takeda K]]
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[[Category: Fad and 4-hydroxyphenylacetate complex]]
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[[Category: Mutant]]
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[[Category: Oxidoreductase]]
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[[Category: Oxygnase component]]
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[[Category: Riken spring-8 center]]
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[[Category: Structurome]]
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[[Category: Two-component flavin diffusible monooxygenase]]
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Current revision

Crystal structure of the mutant of HpaB (T198I, A276G, and R466H) complexed with FAD and 4-hydroxyphenylacetate

PDB ID 2yym

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Proteopedia Page Contributors and Editors (what is this?)

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