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2zq9

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Current revision (13:48, 1 November 2023) (edit) (undo)
 
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<StructureSection load='2zq9' size='340' side='right'caption='[[2zq9]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
<StructureSection load='2zq9' size='340' side='right'caption='[[2zq9]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2zq9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZQ9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2zq9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZQ9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEO:5-METHYLENE-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC+ACID'>CEO</scene>, <scene name='pdbligand=CLS:CEPHALOTHIN'>CLS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SPA:THIOPHENEACETIC+ACID'>SPA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.07&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zq7|2zq7]], [[2zq8|2zq8]], [[2zqa|2zqa]], [[2zqc|2zqc]], [[2zqd|2zqd]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEO:5-METHYLENE-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC+ACID'>CEO</scene>, <scene name='pdbligand=CLS:CEPHALOTHIN'>CLS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SPA:THIOPHENEACETIC+ACID'>SPA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bla ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zq9 OCA], [https://pdbe.org/2zq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zq9 RCSB], [https://www.ebi.ac.uk/pdbsum/2zq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zq9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zq9 OCA], [https://pdbe.org/2zq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zq9 RCSB], [https://www.ebi.ac.uk/pdbsum/2zq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zq9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity.
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[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX] Has strong cefotaxime-hydrolyzing activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ishii, Y]]
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[[Category: Ishii Y]]
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[[Category: Matsuzawa, H]]
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[[Category: Matsuzawa H]]
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[[Category: Miyano, M]]
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[[Category: Miyano M]]
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[[Category: Nitanai, Y]]
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[[Category: Nitanai Y]]
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[[Category: Shimamura, T]]
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[[Category: Shimamura T]]
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[[Category: Takehira, M]]
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[[Category: Takehira M]]
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[[Category: Uchiyama, T]]
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[[Category: Uchiyama T]]
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[[Category: Yutani, K]]
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[[Category: Yutani K]]
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[[Category: Acyl-enzyme]]
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[[Category: Antibiotic resistance]]
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[[Category: Cephalothin]]
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[[Category: Complex]]
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[[Category: Esbl]]
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[[Category: Extended-spectrum]]
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[[Category: Hydrolase]]
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[[Category: Plasmid]]
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[[Category: Toho-1]]
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Current revision

Cephalothin acyl-intermediate structure of class a beta-lactamase Toho-1 E166A/R274N/R276N triple mutant

PDB ID 2zq9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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