3m61

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Current revision (16:30, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3m61' size='340' side='right'caption='[[3m61]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
<StructureSection load='3m61' size='340' side='right'caption='[[3m61]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3m61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M61 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3m61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M61 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nwn|2nwn]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLAU ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m61 OCA], [https://pdbe.org/3m61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m61 RCSB], [https://www.ebi.ac.uk/pdbsum/3m61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m61 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m61 OCA], [https://pdbe.org/3m61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m61 RCSB], [https://www.ebi.ac.uk/pdbsum/3m61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m61 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: U-plasminogen activator]]
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[[Category: Andreasen PA]]
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[[Category: Andreasen, P A]]
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[[Category: Chen L]]
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[[Category: Chen, L]]
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[[Category: Huang M]]
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[[Category: Huang, M]]
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[[Category: Jiang L]]
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[[Category: Jiang, L]]
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[[Category: Meehan EJ]]
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[[Category: Meehan, E J]]
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[[Category: Wind T]]
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[[Category: Wind, T]]
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[[Category: Yuan C]]
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[[Category: Yuan, C]]
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[[Category: Blood coagulation]]
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[[Category: Disulfide bond]]
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[[Category: Egf-like domain]]
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[[Category: Fibrinolysis]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Kringle]]
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[[Category: Phosphoprotein]]
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[[Category: Plasminogen activation]]
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[[Category: Protease]]
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[[Category: Protein-ligand complex]]
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[[Category: Secreted]]
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[[Category: Serine protease]]
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[[Category: Serine protease-peptide complex]]
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[[Category: Zymogen]]
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Current revision

Crystal structure of complex of urokinase and a upain-1 variant(W3A) in pH4.6 condition

PDB ID 3m61

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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