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1fof

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{{STRUCTURE_1fof| PDB=1fof | SCENE= }}
{{STRUCTURE_1fof| PDB=1fof | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10'''
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===CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10===
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==Overview==
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We report the crystal structure of a class D beta-lactamase, the broad spectrum enzyme OXA-10 from Pseudomonas aeruginosa at 2.0 A resolution. There are significant differences between the overall fold observed in this structure and those of the evolutionarily related class A and class C beta-lactamases. Furthermore, the structure suggests the unique, cation mediated formation of a homodimer. Kinetic and hydrodynamic data shows that the dimer is a relevant species in solution and is the more active form of the enzyme. Comparison of the molecular details of the active sites of the class A and class C enzymes with the OXA-10 structure reveals that there is no counterpart in OXA-10 to the residues proposed to act as general bases in either of these enzymes (Glu 166 and Tyr 150, respectively). Our structures of the native and chloride inhibited forms of OXA-10 suggest that the class D enzymes have evolved a distinct catalytic mechanism for beta-lactam hydrolysis. Clinical variants of OXA-10 are also discussed in light of the structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_11017203}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11017203 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11017203}}
==About this Structure==
==About this Structure==
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[[Category: Oxa-10]]
[[Category: Oxa-10]]
[[Category: Oxacillinase]]
[[Category: Oxacillinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:34:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:40:58 2008''

Revision as of 00:41, 1 July 2008

Image:1fof.png

Template:STRUCTURE 1fof

CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10

Template:ABSTRACT PUBMED 11017203

About this Structure

1FOF is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Crystal structure of the class D beta-lactamase OXA-10., Paetzel M, Danel F, de Castro L, Mosimann SC, Page MG, Strynadka NC, Nat Struct Biol. 2000 Oct;7(10):918-25. PMID:11017203

Page seeded by OCA on Tue Jul 1 03:40:58 2008

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