This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


7msj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:19, 18 October 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='7msj' size='340' side='right'caption='[[7msj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='7msj' size='340' side='right'caption='[[7msj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[7msj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MSJ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[7msj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MSJ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7msj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7msj OCA], [https://pdbe.org/7msj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7msj RCSB], [https://www.ebi.ac.uk/pdbsum/7msj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7msj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7msj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7msj OCA], [https://pdbe.org/7msj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7msj RCSB], [https://www.ebi.ac.uk/pdbsum/7msj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7msj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/TNR14_MOUSE TNR14_MOUSE]] Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (By similarity). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (By similarity). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:25711213). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (PubMed:22801499). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (By similarity). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044, PubMed:15568026). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044, PubMed:15568026).[UniProtKB:Q92956]<ref>PMID:15568026</ref> <ref>PMID:19915044</ref> <ref>PMID:22801499</ref> <ref>PMID:25711213</ref>
+
[https://www.uniprot.org/uniprot/TNR14_MOUSE TNR14_MOUSE] Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (By similarity). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (By similarity). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:25711213). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (PubMed:22801499). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (By similarity). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044, PubMed:15568026). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044, PubMed:15568026).[UniProtKB:Q92956]<ref>PMID:15568026</ref> <ref>PMID:19915044</ref> <ref>PMID:22801499</ref> <ref>PMID:25711213</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 19:
</div>
</div>
<div class="pdbe-citations 7msj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7msj" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 23: Line 27:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Almo, S C]]
+
[[Category: Mus musculus]]
-
[[Category: Bonanno, J B]]
+
[[Category: Almo SC]]
-
[[Category: Fedorov, E]]
+
[[Category: Bonanno JB]]
-
[[Category: Garrett-Thompson, S C]]
+
[[Category: Fedorov E]]
-
[[Category: Liu, W]]
+
[[Category: Garrett-Thompson SC]]
-
[[Category: Ramagopal, U]]
+
[[Category: Liu W]]
-
[[Category: Cell membrane]]
+
[[Category: Ramagopal U]]
-
[[Category: Cysteine rich domain]]
+
-
[[Category: Cytokine]]
+
-
[[Category: Immune system]]
+
-
[[Category: Immunity]]
+
-
[[Category: Membrane]]
+
-
[[Category: N-glycosylation]]
+
-
[[Category: Secreted protein]]
+
-
[[Category: Signaling]]
+
-
[[Category: Tnf receptor]]
+

Current revision

The crystal structure of mouse HVEM

PDB ID 7msj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7msj"
Personal tools