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1fol

From Proteopedia

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[[Image:1fol.gif|left|200px]]
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{{Seed}}
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[[Image:1fol.png|left|200px]]
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{{STRUCTURE_1fol| PDB=1fol | SCENE= }}
{{STRUCTURE_1fol| PDB=1fol | SCENE= }}
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'''REDUCED BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG(H4B-FREE)'''
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===REDUCED BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG(H4B-FREE)===
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==Overview==
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The crystal structure of the endothelial nitric oxide synthase (NOS) heme domain complexed with NO reveals close hydrogen bonding interactions between NO and the terminal guanidino nitrogen of the substrate, L-arginine. Dioxygen is expected to bind in a similar mode which will facilitate proton abstraction from L-Arg to dioxygen, a required step for O-O bond cleavage. Structures of mechanism-based NOS inhibitors, N(5)-(1-iminoethyl)-L-ornithine and N-(3-(aminomethyl)benzyl)acetamidine, provide clues on how this class of compounds operate as suicide substrate inhibitors leading to heme oxidation.
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The line below this paragraph, {{ABSTRACT_PUBMED_11331003}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11331003 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11331003}}
==About this Structure==
==About this Structure==
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[[Category: Alpha-beta fold]]
[[Category: Alpha-beta fold]]
[[Category: Nitric oxide synthase]]
[[Category: Nitric oxide synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:34:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:41:35 2008''

Revision as of 00:41, 1 July 2008

Image:1fol.png

Template:STRUCTURE 1fol

REDUCED BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG(H4B-FREE)

Template:ABSTRACT PUBMED 11331003

About this Structure

1FOL is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors., Li H, Raman CS, Martasek P, Masters BS, Poulos TL, Biochemistry. 2001 May 8;40(18):5399-406. PMID:11331003

Page seeded by OCA on Tue Jul 1 03:41:35 2008

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