1zlc

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==Solution Conformation of alpha-conotoxin PIA==
==Solution Conformation of alpha-conotoxin PIA==
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<StructureSection load='1zlc' size='340' side='right'caption='[[1zlc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1zlc' size='340' side='right'caption='[[1zlc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zlc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZLC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zlc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_purpurascens Conus purpurascens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZLC FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlc OCA], [https://pdbe.org/1zlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zlc RCSB], [https://www.ebi.ac.uk/pdbsum/1zlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zlc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlc OCA], [https://pdbe.org/1zlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zlc RCSB], [https://www.ebi.ac.uk/pdbsum/1zlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zlc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CA1A_CONPU CA1A_CONPU]] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin blocks nAChR (alpha-6 or -3/beta-2 or -3 > alpha-3/beta-2 > alpha-3/beta-4). Does not block the muscle nor the major neuronal nAChR alpha-4/beta-2. Discriminates between nAChRs containing alpha-6 and alpha-3 subunits, being selective for alpha-6.<ref>PMID:13679412</ref>
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[https://www.uniprot.org/uniprot/CA1A_CONPU CA1A_CONPU] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin blocks nAChR (alpha-6 or -3/beta-2 or -3 > alpha-3/beta-2 > alpha-3/beta-4). Does not block the muscle nor the major neuronal nAChR alpha-4/beta-2. Discriminates between nAChRs containing alpha-6 and alpha-3 subunits, being selective for alpha-6.<ref>PMID:13679412</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Conus purpurascens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chi, S W]]
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[[Category: Chi S-W]]
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[[Category: Han, K H]]
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[[Category: Han K-H]]
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[[Category: Kim, D H]]
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[[Category: Kim D-H]]
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[[Category: Kim, J S]]
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[[Category: Kim J-S]]
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[[Category: Lee, S H]]
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[[Category: Lee S-H]]
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[[Category: McIntosh, J M]]
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[[Category: McIntosh JM]]
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[[Category: Olivera, B M]]
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[[Category: Olivera BM]]
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[[Category: Alpha-helix]]
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[[Category: Beta-turn]]
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[[Category: C-terminal amidation]]
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[[Category: Toxin]]
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[[Category: Two disulfide bond]]
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Revision as of 09:31, 6 December 2023

Solution Conformation of alpha-conotoxin PIA

PDB ID 1zlc

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