1fow

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[[Image:1fow.gif|left|200px]]
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{{STRUCTURE_1fow| PDB=1fow | SCENE= }}
{{STRUCTURE_1fow| PDB=1fow | SCENE= }}
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'''NMR STRUCTURE OF L11-C76, THE C-TERMINAL DOMAIN OF 50S RIBOSOMAL PROTEIN L11, MINIMIZED AVERAGE STRUCTURE'''
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===NMR STRUCTURE OF L11-C76, THE C-TERMINAL DOMAIN OF 50S RIBOSOMAL PROTEIN L11, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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The structure of the C-terminal RNA recognition domain of ribosomal protein L11 has been solved by heteronuclear three-dimensional nuclear magnetic resonance spectroscopy. Although the structure can be considered high resolution in the core, 15 residues between helix alpha 1 and strand beta 1 form an extended, unstructured loop. 15N transverse relaxation measurements suggest that the loop is moving on a picosecond-to-nanosecond time scale in the free protein but not in the protein bound to RNA. Chemical shifts differences between the free protein and the bound protein suggest that the loop as well as the C-terminal end of helix alpha 3 are involved in RNA binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_8989327}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8989327 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8989327}}
==About this Structure==
==About this Structure==
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1FOW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOW OCA].
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1FOW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOW OCA].
==Reference==
==Reference==
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[[Category: Ribosomal protein]]
[[Category: Ribosomal protein]]
[[Category: Rna-binding domain]]
[[Category: Rna-binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:35:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:42:28 2008''

Revision as of 00:42, 1 July 2008

Image:1fow.png

Template:STRUCTURE 1fow

NMR STRUCTURE OF L11-C76, THE C-TERMINAL DOMAIN OF 50S RIBOSOMAL PROTEIN L11, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 8989327

About this Structure

1FOW is a Single protein structure of sequence from Geobacillus stearothermophilus. Full experimental information is available from OCA.

Reference

High resolution solution structure of ribosomal protein L11-C76, a helical protein with a flexible loop that becomes structured upon binding to RNA., Markus MA, Hinck AP, Huang S, Draper DE, Torchia DA, Nat Struct Biol. 1997 Jan;4(1):70-7. PMID:8989327

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