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1fph

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{{STRUCTURE_1fph| PDB=1fph | SCENE= }}
{{STRUCTURE_1fph| PDB=1fph | SCENE= }}
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'''THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY'''
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===THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY===
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==Overview==
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The structure of the ternary complex of human alpha-thrombin with a covalently bound analogue of fibrinopeptide A and a C-terminal hirudin peptide has been determined by X-ray diffraction methods at 0.25 nm resolution. Fibrinopeptide A folds in a compact manner, bringing together hydrophobic residues that slot into the apolar binding site of human alpha-thrombin. Fibrinogen residue Phe8 occupies the aryl-binding site of thrombin, adjacent to fibrinogen residues Leu9 and Val15 in the S2 subsite. The species diversity of fibrinopeptide A is analysed with respect to its conformation and its interaction with thrombin. The non-covalently attached peptide fragment hirudin(54-65) exhibits an identical conformation to that observed in the hirudin-thrombin complex. The occupancy of the secondary fibrinogen-recognition exosite by this peptide imposes restrictions on the manner of fibrinogen binding. The surface topology of the thrombin molecule indicates positions P1'-P3', differ from those of the canonical serine-proteinase inhibitors, suggesting a mechanical model for the switching of thrombin activity from fibrinogen cleavage to protein-C activation on thrombomodulin complex formation. The multiple interactions between thrombin and fibrinogen provide an explanation for the narrow specificity of thrombin. Structural grounds can be put forward for certain congenital clotting disorders.
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(as it appears on PubMed at http://www.pubmed.gov), where 1587268 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1587268}}
==About this Structure==
==About this Structure==
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[[Category: Bode, W.]]
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[[Category: Stubbs, M T.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:44:16 2008''

Revision as of 00:44, 1 July 2008

Image:1fph.png

Template:STRUCTURE 1fph

THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY

Template:ABSTRACT PUBMED 1587268

About this Structure

1FPH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The interaction of thrombin with fibrinogen. A structural basis for its specificity., Stubbs MT, Oschkinat H, Mayr I, Huber R, Angliker H, Stone SR, Bode W, Eur J Biochem. 1992 May 15;206(1):187-95. PMID:1587268

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