5qc7
From Proteopedia
(Difference between revisions)
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==Crystal structure of human Cathepsin-S with bound ligand== | ==Crystal structure of human Cathepsin-S with bound ligand== | ||
| - | <StructureSection load='5qc7' size='340' side='right'caption='[[5qc7]]' scene=''> | + | <StructureSection load='5qc7' size='340' side='right'caption='[[5qc7]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QC7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5qc7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QC7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qc7 OCA], [https://pdbe.org/5qc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qc7 RCSB], [https://www.ebi.ac.uk/pdbsum/5qc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qc7 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BQS:2-[1-(cyclohexylmethyl)piperidin-4-yl]-1-{3-[3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-4-(trifluoromethyl)phenyl]-1-propyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one'>BQS</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qc7 OCA], [https://pdbe.org/5qc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qc7 RCSB], [https://www.ebi.ac.uk/pdbsum/5qc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qc7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ameriks MK]] | [[Category: Ameriks MK]] | ||
Revision as of 14:10, 1 February 2024
Crystal structure of human Cathepsin-S with bound ligand
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Categories: Homo sapiens | Large Structures | Ameriks MK | Bembenek SD | Burley SK | Mirzadegan T | Shao C | Yang H
