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7lau

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Current revision (15:42, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7lau' size='340' side='right'caption='[[7lau]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='7lau' size='340' side='right'caption='[[7lau]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7lau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LAU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7lau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LAU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VYJ:11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one'>VYJ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VYJ:11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one'>VYJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lau OCA], [https://pdbe.org/7lau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lau RCSB], [https://www.ebi.ac.uk/pdbsum/7lau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lau ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lau OCA], [https://pdbe.org/7lau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lau RCSB], [https://www.ebi.ac.uk/pdbsum/7lau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lau ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/U3KQA6_HUMAN U3KQA6_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7lau" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7lau" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bikowitz, M]]
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[[Category: Bikowitz M]]
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[[Category: Karim, M R]]
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[[Category: Karim MR]]
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[[Category: Schonbrunn, E]]
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[[Category: Schonbrunn E]]
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[[Category: Bet]]
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[[Category: Dual brd-kinase inhibitor]]
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[[Category: Erk5]]
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[[Category: Gene regulation]]
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Current revision

Crystal structure of the first bromodomain (BD1) of human BRD2 bound to ERK5-IN-1

PDB ID 7lau

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OCA

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