7nxr

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Current revision (07:50, 1 May 2024) (edit) (undo)
 
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<StructureSection load='7nxr' size='340' side='right'caption='[[7nxr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='7nxr' size='340' side='right'caption='[[7nxr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7nxr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NXR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7nxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murid_gammaherpesvirus_4 Murid gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NXR FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7nxp|7nxp]], [[7nxq|7nxq]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nxr OCA], [https://pdbe.org/7nxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nxr RCSB], [https://www.ebi.ac.uk/pdbsum/7nxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nxr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nxr OCA], [https://pdbe.org/7nxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nxr RCSB], [https://www.ebi.ac.uk/pdbsum/7nxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nxr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/O41938_MHV68 O41938_MHV68]] Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.[HAMAP-Rule:MF_04025]
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[https://www.uniprot.org/uniprot/O41938_MHV68 O41938_MHV68] Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.[HAMAP-Rule:MF_04025]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Herpesviruses cause severe diseases particularly in immunocompromised patients. Both genome packaging and release from the capsid require a unique portal channel occupying one of the 12 capsid vertices. Here, we report the 2.6 A crystal structure of the pentameric pORF19 of the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) resembling the portal cap that seals this portal channel. We also present the structure of its beta-herpesviral ortholog, revealing a striking structural similarity to its alpha- and gamma-herpesviral counterparts despite apparent differences in capsid association. We demonstrate pORF19 pentamer formation in solution and provide insights into how pentamerization is triggered in infected cells. Mutagenesis in its lateral interfaces blocked pORF19 pentamerization and severely affected KSHV capsid assembly and production of infectious progeny. Our results pave the way to better understand the role of pORF19 in capsid assembly and identify a potential novel drug target for the treatment of herpesvirus-induced diseases.
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Assembly of infectious Kaposi's sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer.,Naniima P, Naimo E, Koch S, Curth U, Alkharsah KR, Stroh LJ, Binz A, Beneke JM, Vollmer B, Boning H, Borst EM, Desai P, Bohne J, Messerle M, Bauerfeind R, Legrand P, Sodeik B, Schulz TF, Krey T PLoS Biol. 2021 Nov 4;19(11):e3001423. doi: 10.1371/journal.pbio.3001423., eCollection 2021 Nov. PMID:34735435<ref>PMID:34735435</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7nxr" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Krey, T]]
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[[Category: Murid gammaherpesvirus 4]]
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[[Category: Legrand, P]]
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[[Category: Krey T]]
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[[Category: Naniima, P]]
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[[Category: Legrand P]]
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[[Category: Assembly]]
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[[Category: Naniima P]]
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[[Category: Capsid]]
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[[Category: Herpesvirus]]
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[[Category: Muhv-68]]
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[[Category: Viral protein]]
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Current revision

Structure of the C-terminal domain of the pORF19 capsid protein from murid gammaherpesvirus 68 (MuHV-68)

PDB ID 7nxr

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OCA

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