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2ajn

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Current revision (16:32, 13 December 2023) (edit) (undo)
 
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==NMR structure of the in-plane membrane anchor domain [1-28] of the monotopic NonStructural Protein 5A (NS5A) from the Bovine Viral Diarrhea Virus (BVDV)==
==NMR structure of the in-plane membrane anchor domain [1-28] of the monotopic NonStructural Protein 5A (NS5A) from the Bovine Viral Diarrhea Virus (BVDV)==
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<StructureSection load='2ajn' size='340' side='right'caption='[[2ajn]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='2ajn' size='340' side='right'caption='[[2ajn]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ajn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AJN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ajn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1-CP7 Bovine viral diarrhea virus 1-CP7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AJN FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ajj|2ajj]], [[2ajm|2ajm]], [[2ajo|2ajo]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ajn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajn OCA], [https://pdbe.org/2ajn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ajn RCSB], [https://www.ebi.ac.uk/pdbsum/2ajn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ajn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajn OCA], [https://pdbe.org/2ajn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ajn RCSB], [https://www.ebi.ac.uk/pdbsum/2ajn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/POLG_BVDVC POLG_BVDVC]] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (By similarity). P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity). Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus. NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.
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[https://www.uniprot.org/uniprot/POLG_BVDVC POLG_BVDVC] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (By similarity). P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity). Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus. NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bovine viral diarrhea virus 1-CP7]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brass, V]]
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[[Category: Brass V]]
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[[Category: Chipot, C]]
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[[Category: Chipot C]]
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[[Category: Deleage, G]]
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[[Category: Deleage G]]
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[[Category: Montserret, R]]
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[[Category: Montserret R]]
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[[Category: Moradpour, D]]
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[[Category: Moradpour D]]
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[[Category: Penin, F]]
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[[Category: Penin F]]
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[[Category: Sapay, N]]
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[[Category: Sapay N]]
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[[Category: Amphipathic alpha-helix]]
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[[Category: In-plane membrane anchor domain]]
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[[Category: Membrane protein]]
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Current revision

NMR structure of the in-plane membrane anchor domain [1-28] of the monotopic NonStructural Protein 5A (NS5A) from the Bovine Viral Diarrhea Virus (BVDV)

PDB ID 2ajn

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