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2y2u

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Current revision (08:07, 23 August 2023) (edit) (undo)
 
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<StructureSection load='2y2u' size='340' side='right'caption='[[2y2u]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2y2u' size='340' side='right'caption='[[2y2u]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y2u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jgh 2jgh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y2U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y2u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jgh 2jgh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y2U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SVX:O-[(R)-ETHOXY(METHYL)PHOSPHORYL]-L-SERINE'>SVX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SVX:O-[(R)-ETHOXY(METHYL)PHOSPHORYL]-L-SERINE'>SVX</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2whq|2whq]], [[2jgh|2jgh]], [[1mah|1mah]], [[2ha6|2ha6]], [[1maa|1maa]], [[2jgg|2jgg]], [[2c0q|2c0q]], [[2jgl|2jgl]], [[2xug|2xug]], [[1q84|1q84]], [[2xud|2xud]], [[2jgm|2jgm]], [[2xuj|2xuj]], [[1q83|1q83]], [[2jge|2jge]], [[2wls|2wls]], [[2xup|2xup]], [[2xuk|2xuk]], [[2ha3|2ha3]], [[1c2b|1c2b]], [[2ha0|2ha0]], [[2xuf|2xuf]], [[2wu3|2wu3]], [[2jey|2jey]], [[2jgi|2jgi]], [[1n5r|1n5r]], [[2xuh|2xuh]], [[2jgj|2jgj]], [[1j06|1j06]], [[2jf0|2jf0]], [[2c0p|2c0p]], [[2xuo|2xuo]], [[2xui|2xui]], [[2whr|2whr]], [[2h9y|2h9y]], [[1n5m|1n5m]], [[2xuq|2xuq]], [[2ha2|2ha2]], [[2ha5|2ha5]], [[2whp|2whp]], [[4a23|4a23]], [[2jez|2jez]], [[2jgk|2jgk]], [[1ku6|1ku6]], [[2ha4|2ha4]], [[1j07|1j07]], [[2jgf|2jgf]], [[2ha7|2ha7]], [[2wu4|2wu4]], [[2y2v|2y2v]], [[4a16|4a16]], [[1c2o|1c2o]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y2u OCA], [https://pdbe.org/2y2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y2u RCSB], [https://www.ebi.ac.uk/pdbsum/2y2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y2u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y2u OCA], [https://pdbe.org/2y2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y2u RCSB], [https://www.ebi.ac.uk/pdbsum/2y2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y2u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
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[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acetylcholinesterase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Akfur, C]]
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[[Category: Akfur C]]
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[[Category: Artursson, E]]
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[[Category: Artursson E]]
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[[Category: Ekstrom, F]]
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[[Category: Ekstrom F]]
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[[Category: Cholinesterase]]
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[[Category: Hydrolase]]
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[[Category: Methylphosphonate]]
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Current revision

Nonaged form of Mouse Acetylcholinesterase inhibited by VX-Update

PDB ID 2y2u

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