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7p76

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Current revision (13:01, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7p76' size='340' side='right'caption='[[7p76]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='7p76' size='340' side='right'caption='[[7p76]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7p76]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P76 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7p76]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_909945-2 Escherichia coli 909945-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P76 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9Y6:(2E)-3-phenylprop-2-enal'>9Y6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7p75|7p75]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9Y6:(2E)-3-phenylprop-2-enal'>9Y6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Deoxyribose-phosphate_aldolase Deoxyribose-phosphate aldolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.4 4.1.2.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p76 OCA], [https://pdbe.org/7p76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p76 RCSB], [https://www.ebi.ac.uk/pdbsum/7p76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p76 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p76 OCA], [https://pdbe.org/7p76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p76 RCSB], [https://www.ebi.ac.uk/pdbsum/7p76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p76 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/V0AAC4_ECOLX V0AAC4_ECOLX]] Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.[HAMAP-Rule:MF_00592]
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[https://www.uniprot.org/uniprot/V0AAC4_ECOLX V0AAC4_ECOLX] Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.[HAMAP-Rule:MF_00592]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7p76" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7p76" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aldolase 3D structures|Aldolase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Deoxyribose-phosphate aldolase]]
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[[Category: Escherichia coli 909945-2]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kunzendorf, A]]
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[[Category: Kunzendorf A]]
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[[Category: Poelarends, G J]]
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[[Category: Poelarends GJ]]
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[[Category: Rozeboom, H J]]
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[[Category: Rozeboom HJ]]
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[[Category: Thunnissen, A M.W H]]
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[[Category: Thunnissen AMWH]]
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[[Category: Aldolase]]
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[[Category: Carboligase]]
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[[Category: Carbon-carbon lyase]]
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[[Category: Cinnamaldehyde]]
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[[Category: Directed evolution]]
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[[Category: Lyase]]
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[[Category: Michael addition]]
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[[Category: Protein engineering]]
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[[Category: Schiff base]]
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Current revision

Re-engineered 2-deoxy-D-ribose-5-phosphate aldolase catalysing asymmetric Michael addition reactions, Schiff base complex with cinnamaldehyde

PDB ID 7p76

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OCA

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