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2bt4

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Current revision (13:55, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2bt4' size='340' side='right'caption='[[2bt4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2bt4' size='340' side='right'caption='[[2bt4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2bt4]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BT4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2bt4]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BT4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA2:(1S,3R,4R,5S)-1,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)CYCLOHEXANECARBOXYLIC+ACID'>CA2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d0i|1d0i]], [[1gtz|1gtz]], [[1gu0|1gu0]], [[1gu1|1gu1]], [[1v1j|1v1j]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA2:(1S,3R,4R,5S)-1,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)CYCLOHEXANECARBOXYLIC+ACID'>CA2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bt4 OCA], [https://pdbe.org/2bt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bt4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bt4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bt4 OCA], [https://pdbe.org/2bt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bt4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bt4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AROQ_STRCO AROQ_STRCO]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
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[https://www.uniprot.org/uniprot/AROQ_STRCO AROQ_STRCO] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3-dehydroquinate dehydratase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abell, C]]
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[[Category: Streptomyces coelicolor]]
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[[Category: Coggins, J R]]
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[[Category: Abell C]]
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[[Category: Lapthorn, A J]]
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[[Category: Coggins JR]]
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[[Category: Stewart, K A]]
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[[Category: Lapthorn AJ]]
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[[Category: Toscano, M D]]
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[[Category: Stewart KA]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Toscano MD]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Dehydroquinate]]
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[[Category: Lyase]]
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[[Category: Shikimate pathway]]
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Current revision

Type II Dehydroquinase inhibitor complex

PDB ID 2bt4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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