2jrz

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==Solution structure of the Bright/ARID domain from the human JARID1C protein.==
==Solution structure of the Bright/ARID domain from the human JARID1C protein.==
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<StructureSection load='2jrz' size='340' side='right'caption='[[2jrz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2jrz' size='340' side='right'caption='[[2jrz]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jrz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JRZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jrz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JRZ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">JARID1C, DXS1272E, SMCX, XE169 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrz OCA], [https://pdbe.org/2jrz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jrz RCSB], [https://www.ebi.ac.uk/pdbsum/2jrz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrz OCA], [https://pdbe.org/2jrz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jrz RCSB], [https://www.ebi.ac.uk/pdbsum/2jrz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrz ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/KDM5C_HUMAN KDM5C_HUMAN]] Syndromic X-linked intellectual disability due to JARID1C mutation. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/KDM5C_HUMAN KDM5C_HUMAN] Syndromic X-linked intellectual disability due to JARID1C mutation. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KDM5C_HUMAN KDM5C_HUMAN]] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).[UniProtKB:P41230]<ref>PMID:17320160</ref> <ref>PMID:17320161</ref> <ref>PMID:17468742</ref>
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[https://www.uniprot.org/uniprot/KDM5C_HUMAN KDM5C_HUMAN] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).[UniProtKB:P41230]<ref>PMID:17320160</ref> <ref>PMID:17320161</ref> <ref>PMID:17468742</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Ball, L J]]
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[[Category: Ball LJ]]
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[[Category: Bishop, S]]
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[[Category: Bishop S]]
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[[Category: Diehl, A]]
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[[Category: Diehl A]]
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[[Category: Dowler, E F]]
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[[Category: Dowler EF]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Koehler, C]]
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[[Category: Koehler C]]
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[[Category: Leidert, M]]
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[[Category: Leidert M]]
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[[Category: Oschkinat, H]]
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[[Category: Oschkinat H]]
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[[Category: Structural genomic]]
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[[Category: Schmieder P]]
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[[Category: Schmieder, P]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Wiegelt J]]
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[[Category: Wiegelt, J]]
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[[Category: Bright/arid domain]]
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[[Category: Helical]]
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[[Category: Jarid1c]]
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[[Category: Oxidoreductase]]
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[[Category: Sgc]]
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Revision as of 08:36, 14 June 2023

Solution structure of the Bright/ARID domain from the human JARID1C protein.

PDB ID 2jrz

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OCA

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