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2jzb

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Current revision (06:43, 1 May 2024) (edit) (undo)
 
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==Solution structure of the complex between E.coli NusA-AR2 and RNAP-aCTD==
==Solution structure of the complex between E.coli NusA-AR2 and RNAP-aCTD==
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<StructureSection load='2jzb' size='340' side='right'caption='[[2jzb]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2jzb' size='340' side='right'caption='[[2jzb]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jzb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [https://en.wikipedia.org/wiki/"bacillus_pseudotuberkulosis"_(sic)_pfeiffer_1889 "bacillus pseudotuberkulosis" (sic) pfeiffer 1889]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JZB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jzb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Yersinia_pseudotuberculosis Yersinia pseudotuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JZB FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rpoA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=633 "Bacillus pseudotuberkulosis" (sic) Pfeiffer 1889]), nusA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzb OCA], [https://pdbe.org/2jzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jzb RCSB], [https://www.ebi.ac.uk/pdbsum/2jzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzb OCA], [https://pdbe.org/2jzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jzb RCSB], [https://www.ebi.ac.uk/pdbsum/2jzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059] [[https://www.uniprot.org/uniprot/NUSA_ECOLI NUSA_ECOLI]] Participates in both transcription termination and antitermination. Involved in a variety of cellular and viral termination and antitermination processes, such as Rho-dependent transcriptional termination, intrinsic termination, and phage lambda N-mediated transcriptional antitermination. Also important for coordinating the cellular responses to DNA damage by coupling the processes of nucleotide excision repair and translesion synthesis to transcription.<ref>PMID:6263495</ref> <ref>PMID:6265785</ref> <ref>PMID:6199039</ref> <ref>PMID:2821282</ref> <ref>PMID:7536848</ref> <ref>PMID:9139668</ref> <ref>PMID:11719185</ref> <ref>PMID:20696893</ref> <ref>PMID:21922055</ref>
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[https://www.uniprot.org/uniprot/RPOA_YERPS RPOA_YERPS] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Prasch, S]]
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[[Category: Yersinia pseudotuberculosis]]
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[[Category: Roesch, P]]
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[[Category: Prasch S]]
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[[Category: Schweimer, K]]
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[[Category: Roesch P]]
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[[Category: Dna-directed rna polymerase]]
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[[Category: Schweimer K]]
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[[Category: Helix-hairpin-helix]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Nusa]]
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[[Category: Rna-binding]]
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[[Category: Rnap]]
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[[Category: Stress response]]
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[[Category: Transcription]]
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[[Category: Transcription antitermination]]
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[[Category: Transcription regulation]]
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[[Category: Transcription termination]]
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[[Category: Transferase]]
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[[Category: Transferase-transcription complex]]
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Current revision

Solution structure of the complex between E.coli NusA-AR2 and RNAP-aCTD

PDB ID 2jzb

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