2k50
From Proteopedia
(Difference between revisions)
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==Solution NMR Structure of the replication Factor A Related Protein from Methanobacterium thermoautotrophicum. Northeast Structural Genomics Target TR91A.== | ==Solution NMR Structure of the replication Factor A Related Protein from Methanobacterium thermoautotrophicum. Northeast Structural Genomics Target TR91A.== | ||
| - | <StructureSection load='2k50' size='340' side='right'caption='[[2k50 | + | <StructureSection load='2k50' size='340' side='right'caption='[[2k50]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2k50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2k50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K50 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k50 OCA], [https://pdbe.org/2k50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k50 RCSB], [https://www.ebi.ac.uk/pdbsum/2k50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k50 ProSAT], [https://www.topsan.org/Proteins/NESGC/2k50 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k50 OCA], [https://pdbe.org/2k50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k50 RCSB], [https://www.ebi.ac.uk/pdbsum/2k50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k50 ProSAT], [https://www.topsan.org/Proteins/NESGC/2k50 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/RPA_METTH RPA_METTH] Inhibits DNA polymerase activity of PolB, which can be overcome by RFC and PNCA. Stimulates 3'-to 5'-exonuclease activity of PolB at 30 degrees Celsius, but has no effect at 50 or 70 degrees Celsius. Bind ssDNA and replication forks; replication forks structures bind both Hel308 and this protein. Has no effect on helicase activity of Hel308; may help target the helicase to DNA substrates that require DNA re-modeling.<ref>PMID:10497247</ref> <ref>PMID:21195035</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Methanothermobacter thermautotrophicus str. Delta H]] |
| - | [[Category: Acton | + | [[Category: Acton TB]] |
| - | [[Category: Ciccosanti | + | [[Category: Ciccosanti C]] |
| - | [[Category: Everett | + | [[Category: Everett JK]] |
| - | [[Category: Foote | + | [[Category: Foote EL]] |
| - | [[Category: Jiang | + | [[Category: Jiang M]] |
| - | [[Category: Maglaqui | + | [[Category: Maglaqui M]] |
| - | [[Category: Montelione | + | [[Category: Montelione GT]] |
| - | + | [[Category: Nair R]] | |
| - | [[Category: Nair | + | [[Category: Rossi P]] |
| - | [[Category: Rossi | + | [[Category: Rost B]] |
| - | [[Category: Rost | + | [[Category: Swapna G]] |
| - | [[Category: Swapna | + | [[Category: Xiao R]] |
| - | [[Category: Xiao | + | |
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Current revision
Solution NMR Structure of the replication Factor A Related Protein from Methanobacterium thermoautotrophicum. Northeast Structural Genomics Target TR91A.
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