1fs8

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{{STRUCTURE_1fs8| PDB=1fs8 | SCENE= }}
{{STRUCTURE_1fs8| PDB=1fs8 | SCENE= }}
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'''CYTOCHROME C NITRITE REDUCTASE FROM WOLINELLA SUCCINOGENES-SULFATE COMPLEX'''
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===CYTOCHROME C NITRITE REDUCTASE FROM WOLINELLA SUCCINOGENES-SULFATE COMPLEX===
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==Overview==
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Cytochrome c nitrite reductase catalyzes the 6-electron reduction of nitrite to ammonia. This second part of the respiratory pathway of nitrate ammonification is a key step in the biological nitrogen cycle. The x-ray structure of the enzyme from the epsilon-proteobacterium Wolinella succinogenes has been solved to a resolution of 1.6 A. It is a pentaheme c-type cytochrome whose heme groups are packed in characteristic motifs that also occur in other multiheme cytochromes. Structures of W. succinogenes nitrite reductase have been obtained with water bound to the active site heme iron as well as complexes with two inhibitors, sulfate and azide, whose binding modes and inhibitory functions differ significantly. Cytochrome c nitrite reductase is part of a highly optimized respiratory system found in a wide range of Gram-negative bacteria. It reduces both anionic and neutral substrates at the distal side of a lysine-coordinated high-spin heme group, which is accessible through two different channels, allowing for a guided flow of reaction educt and product. Based on sequence comparison and secondary structure prediction, we have demonstrated that cytochrome c nitrite reductases constitute a protein family of high structural similarity.
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{{ABSTRACT_PUBMED_10984487}}
==About this Structure==
==About this Structure==
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[[Category: Stach, P.]]
[[Category: Stach, P.]]
[[Category: C-type cytochrome]]
[[Category: C-type cytochrome]]
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Revision as of 00:52, 1 July 2008

Image:1fs8.png

Template:STRUCTURE 1fs8

CYTOCHROME C NITRITE REDUCTASE FROM WOLINELLA SUCCINOGENES-SULFATE COMPLEX

Template:ABSTRACT PUBMED 10984487

About this Structure

1FS8 is a Single protein structure of sequence from Wolinella succinogenes. Full crystallographic information is available from OCA.

Reference

Cytochrome c nitrite reductase from Wolinella succinogenes. Structure at 1.6 A resolution, inhibitor binding, and heme-packing motifs., Einsle O, Stach P, Messerschmidt A, Simon J, Kroger A, Huber R, Kroneck PM, J Biol Chem. 2000 Dec 15;275(50):39608-16. PMID:10984487

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