Transmembrane protease serine 2

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responses, tumour cell invasion, apoptosis and
responses, tumour cell invasion, apoptosis and
pain. <ref>DOI 10.1097/j.pain.0000000000000130</ref>
pain. <ref>DOI 10.1097/j.pain.0000000000000130</ref>
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=== Prostate cancer ===
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=== Viral entry ===
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== Structure ==
== Structure ==

Revision as of 16:52, 28 November 2021

TMPRSS2 is a membrane protein belonging to the type II transmembrane serine protease (TTSP) family. It is functionally classified as a trypsin-like protease (TLP). [1] Serine proteases are known to be involved in many physiological and pathological processes.

Caption for this structure

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References

  1. ↑ Sgrignani J, Cavalli A. Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2. Front Mol Biosci. 2021 Apr 30;8:666626. doi: 10.3389/fmolb.2021.666626., eCollection 2021. PMID:33996911 doi:http://dx.doi.org/10.3389/fmolb.2021.666626
  2. ↑ Evnin LB, Vasquez JR, Craik CS. Substrate specificity of trypsin investigated by using a genetic selection. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6659-63. doi: 10.1073/pnas.87.17.6659. PMID:2204062 doi:http://dx.doi.org/10.1073/pnas.87.17.6659
  3. ↑ Singh N, Decroly E, Khatib AM, Villoutreix BO. Structure-based drug repositioning over the human TMPRSS2 protease domain: search for chemical probes able to repress SARS-CoV-2 Spike protein cleavages. Eur J Pharm Sci. 2020 Oct 1;153:105495. doi: 10.1016/j.ejps.2020.105495. Epub, 2020 Jul 28. PMID:32730844 doi:http://dx.doi.org/10.1016/j.ejps.2020.105495
  4. ↑ Lam DK, Dang D, Flynn AN, Hardt M, Schmidt BL. TMPRSS2, a novel membrane-anchored mediator in cancer pain. Pain. 2015 May;156(5):923-930. doi: 10.1097/j.pain.0000000000000130. PMID:25734995 doi:http://dx.doi.org/10.1097/j.pain.0000000000000130
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