1fsc

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{{STRUCTURE_1fsc| PDB=1fsc | SCENE= }}
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'''CRYSTAL STRUCTURE OF FASCICULIN 2 FROM GREEN MAMBA SNAKE VENOM: EVIDENCE FOR UNUSUAL LOOP FLEXIBILITY'''
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===CRYSTAL STRUCTURE OF FASCICULIN 2 FROM GREEN MAMBA SNAKE VENOM: EVIDENCE FOR UNUSUAL LOOP FLEXIBILITY===
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==Overview==
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The crystal structure of the snake toxin fasciculin 2, a potent acetylcholinesterase inhibitor from the venom of the green mamba (Dendroaspis angusticeps), has been determined by the molecular-replacement method, using the fasciculin 1 model and refined to 2.0 A resolution. The introduction of an overall anisotropic temperature factor improved significantly the quality of the electron-density map. It suggests, as it was also indicated by the packing, that the thermal motion along the unique axis direction is less pronounced than on the (ab) plane. The final crystallographic R factor is 0.188 for a model having r.m.s. deviations from ideality of 0.016 A for bond lengths and 2.01 degrees for bond angles. As fasciculin 1, fasciculin 2 belongs to the three-finger class of Elapidae toxins, a structural group that also contains the alpha-neurotoxins and the cardiotoxins. Although the two fasciculins have, overall, closely related structures, the conformation of loop I differs appreciably in the two molecules. The presence of detergent in crystallization medium in the case of fasciculin 2 appears to be responsible for the displacement of the loop containing Thr9. This conformational change also results in the formation of a crystallographic dimer that displays extensive intermolecular interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 15299729 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15299729}}
==About this Structure==
==About this Structure==
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[[Category: Housset, D.]]
[[Category: Housset, D.]]
[[Category: Snake toxin]]
[[Category: Snake toxin]]
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Revision as of 00:52, 1 July 2008

Image:1fsc.png

Template:STRUCTURE 1fsc

CRYSTAL STRUCTURE OF FASCICULIN 2 FROM GREEN MAMBA SNAKE VENOM: EVIDENCE FOR UNUSUAL LOOP FLEXIBILITY

Template:ABSTRACT PUBMED 15299729

About this Structure

1FSC is a Single protein structure of sequence from Dendroaspis angusticeps. Full crystallographic information is available from OCA.

Reference

Structure of fasciculin 2 from green mamba snake venom: evidence for unusual loop flexibility., le Du MH, Housset D, Marchot P, Bougis PE, Navaza J, Fontecilla-Camps JC, Acta Crystallogr D Biol Crystallogr. 1996 Jan 1;52(Pt 1):87-92. PMID:15299729

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