User:Maria Carolina Boer Copstein/Sandbox 1

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Contents 1 Introduction 2 Disease 3 Relevance 4 Structural highlights 5 neurodegenerative diseases

Introduction

VDAC1 is a protein present in the outer mitochondrial membrane(OMM).Mediate exchange of calcium between reticulum and mitochondria and is involved in several cellular processes.VDAC1 has been shown to be a regulator of OMM permeability to Ca2+

Disease

Relevance

Structural highlights

Human VDAC1 (hVDAC1) adopts a β-barrel architecture composed of 19 β-strands with an α-helix located horizontally midway within the pore.

neurodegenerative diseases

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