7swq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Arabidopsis Ago10-guide-target RNA complex in a bent duplex conformation== | |
| - | + | <StructureSection load='7swq' size='340' side='right'caption='[[7swq]], [[Resolution|resolution]] 3.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7swq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SWQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7swq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7swq OCA], [https://pdbe.org/7swq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7swq RCSB], [https://www.ebi.ac.uk/pdbsum/7swq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7swq ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AGO10_ARATH AGO10_ARATH] Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Required for reliable formation of primary and axillary shoot apical meristems. Specifies leaf adaxial identity by repressing the miR165 and miR166 microRNAs in the embryonic shoot apex, in the shoot apical meristem (SAM) and leaf. Represses the microRNA miR398 which targets CCS1 chaperone mRNAs for translational inhibition. Acts as a negative regulator of AGO1 protein level. Like AGO1, is required for stem cell function and organ polarity. Unlike AGO1, is not subjected to small RNA-mediated repression itself. Essential for multiple processes in development. Coregulates, with GATA18/HAN, the shoot apical meristem (SAM) organization (PubMed:26390296).<ref>PMID:12468725</ref> <ref>PMID:19054365</ref> <ref>PMID:19763164</ref> <ref>PMID:20128885</ref> <ref>PMID:26390296</ref> <ref>PMID:9501101</ref> <ref>PMID:9876176</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arabidopsis thaliana]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Unidentified]] | ||
| + | [[Category: MacRae IJ]] | ||
| + | [[Category: Xiao Y]] | ||
Revision as of 10:05, 24 November 2022
Cryo-EM structure of Arabidopsis Ago10-guide-target RNA complex in a bent duplex conformation
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