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1fsz

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{{STRUCTURE_1fsz| PDB=1fsz | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE CELL-DIVISION PROTEIN FTSZ AT 2.8A RESOLUTION'''
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===CRYSTAL STRUCTURE OF THE CELL-DIVISION PROTEIN FTSZ AT 2.8A RESOLUTION===
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==Overview==
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Bacterial cell division ends with septation, the constriction of the cell wall and cell membranes that leads to the formation of two daughter cells. During septation, FtsZ, a protein of relative molecular mass 40,000 which is ubiquitous in eubacteria and is also found in archaea and chloroplasts, localizes early at the division site to form a ring-shaped septum. This septum is required for the mechanochemical process of membrane constriction. FtsZ is a GTPase with weak sequence homology to tubulins. The nature of FtsZ polymers in vivo is unknown, but FtsZ can form tubules, sheets and minirings in vitro. Here we report the crystal structure at 2.8 A resolution of recombinant FtsZ from the hyperthermophilic methanogen Methanococcus jannaschii. FtsZ has two domains, one of which is a GTPase domain with a fold related to one found in the proteins p21ras and elongation factor EF-Tu. The carboxy-terminal domain, whose function is unknown, is a four-stranded beta-sheet tilted by 90 degrees against the beta-sheet of the GTPase domain. The two domains are arranged around a central helix. GDP binding is different from that typically found in GTPases and involves four phosphate-binding loops and a sugar-binding loop in the first domain, with guanine being recognized by residues in the central connecting helix. The three-dimensional structure of FtsZ is similar to the structure of alpha- and beta-tubulin.
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(as it appears on PubMed at http://www.pubmed.gov), where 9428770 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9428770}}
==About this Structure==
==About this Structure==
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[[Category: Ftsz]]
[[Category: Ftsz]]
[[Category: Tubulin]]
[[Category: Tubulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:54:12 2008''

Revision as of 00:54, 1 July 2008

Image:1fsz.png

Template:STRUCTURE 1fsz

CRYSTAL STRUCTURE OF THE CELL-DIVISION PROTEIN FTSZ AT 2.8A RESOLUTION

Template:ABSTRACT PUBMED 9428770

About this Structure

1FSZ is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Crystal structure of the bacterial cell-division protein FtsZ., Lowe J, Amos LA, Nature. 1998 Jan 8;391(6663):203-6. PMID:9428770

Page seeded by OCA on Tue Jul 1 03:54:12 2008

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