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6z3e
From Proteopedia
(Difference between revisions)
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==Crystal structure of GDP-bound human GIMAP5, amino acid residues 1-276== | ==Crystal structure of GDP-bound human GIMAP5, amino acid residues 1-276== | ||
| - | <StructureSection load='6z3e' size='340' side='right'caption='[[6z3e]]' scene=''> | + | <StructureSection load='6z3e' size='340' side='right'caption='[[6z3e]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z3E FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6z3e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z3E FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z3e OCA], [https://pdbe.org/6z3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z3e RCSB], [https://www.ebi.ac.uk/pdbsum/6z3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z3e ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.800387Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z3e OCA], [https://pdbe.org/6z3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z3e RCSB], [https://www.ebi.ac.uk/pdbsum/6z3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z3e ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/GIMA5_HUMAN GIMA5_HUMAN] The disease may be caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GIMA5_HUMAN GIMA5_HUMAN] Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity).[UniProtKB:Q8BWF2][UniProtKB:Q8K3L6]<ref>PMID:29382851</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Daumke O]] | [[Category: Daumke O]] | ||
[[Category: Schwefel D]] | [[Category: Schwefel D]] | ||
Current revision
Crystal structure of GDP-bound human GIMAP5, amino acid residues 1-276
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