7dl4
From Proteopedia
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==Crystal structure of human serum albumin and nitrosylruthenium complex adduct== | ==Crystal structure of human serum albumin and nitrosylruthenium complex adduct== | ||
| - | <StructureSection load='7dl4' size='340' side='right'caption='[[7dl4]]' scene=''> | + | <StructureSection load='7dl4' size='340' side='right'caption='[[7dl4]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DL4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7dl4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DL4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dl4 OCA], [https://pdbe.org/7dl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dl4 RCSB], [https://www.ebi.ac.uk/pdbsum/7dl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dl4 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HZQ:5-chloranylquinolin-8-ol'>HZQ</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dl4 OCA], [https://pdbe.org/7dl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dl4 RCSB], [https://www.ebi.ac.uk/pdbsum/7dl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dl4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Albumin 3D structures|Albumin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Wang HF]] | [[Category: Wang HF]] | ||
[[Category: Wang WM]] | [[Category: Wang WM]] | ||
[[Category: Xie LL]] | [[Category: Xie LL]] | ||
Revision as of 16:35, 29 November 2023
Crystal structure of human serum albumin and nitrosylruthenium complex adduct
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