7mp8
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of the cytosolic domain of Tribolium castaneum PINK1 in the non-phosphorylated state== | ==Crystal structure of the cytosolic domain of Tribolium castaneum PINK1 in the non-phosphorylated state== | ||
| - | <StructureSection load='7mp8' size='340' side='right'caption='[[7mp8]]' scene=''> | + | <StructureSection load='7mp8' size='340' side='right'caption='[[7mp8]], [[Resolution|resolution]] 3.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MP8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7mp8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MP8 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mp8 OCA], [https://pdbe.org/7mp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mp8 RCSB], [https://www.ebi.ac.uk/pdbsum/7mp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mp8 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mp8 OCA], [https://pdbe.org/7mp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mp8 RCSB], [https://www.ebi.ac.uk/pdbsum/7mp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mp8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mutations in PINK1 cause autosomal-recessive Parkinson's disease. Mitochondrial damage results in PINK1 import arrest on the translocase of the outer mitochondrial membrane (TOM) complex, resulting in the activation of its ubiquitin kinase activity by autophosphorylation and initiation of Parkin-dependent mitochondrial clearance. Herein, we report crystal structures of the entire cytosolic domain of insect PINK1. Our structures reveal a dimeric autophosphorylation complex targeting phosphorylation at the invariant Ser205 (human Ser228). The dimer interface requires insert 2, which is unique to PINK1. The structures also reveal how an N-terminal helix binds to the C-terminal extension and provide insights into stabilization of PINK1 on the core TOM complex. | ||
| + | |||
| + | Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex.,Rasool S, Veyron S, Soya N, Eldeeb MA, Lukacs GL, Fon EA, Trempe JF Mol Cell. 2021 Nov 26. pii: S1097-2765(21)00991-6. doi:, 10.1016/j.molcel.2021.11.012. PMID:34875213<ref>PMID:34875213</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7mp8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Rasool S]] | + | [[Category: Rasool, S]] |
| - | [[Category: Trempe | + | [[Category: Trempe, J F]] |
| - | [[Category: Veyron S]] | + | [[Category: Veyron, S]] |
| + | [[Category: Kinase]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Transphorylation]] | ||
Revision as of 15:37, 22 December 2021
Crystal structure of the cytosolic domain of Tribolium castaneum PINK1 in the non-phosphorylated state
| |||||||||||
