1ft9

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[[Image:1ft9.jpg|left|200px]]
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{{Seed}}
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[[Image:1ft9.png|left|200px]]
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{{STRUCTURE_1ft9| PDB=1ft9 | SCENE= }}
{{STRUCTURE_1ft9| PDB=1ft9 | SCENE= }}
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'''STRUCTURE OF THE REDUCED (FEII) CO-SENSING PROTEIN FROM R. RUBRUM'''
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===STRUCTURE OF THE REDUCED (FEII) CO-SENSING PROTEIN FROM R. RUBRUM===
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==Overview==
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CooA is a homodimeric transcription factor that belongs to the catabolite activator protein (CAP) family. Binding of CO to the heme groups of CooA leads to the transcription of genes involved in CO oxidation in Rhodospirillum rubrum. The 2.6 A structure of reduced (Fe2+) CooA reveals that His 77 in both subunits provides one heme ligand while the N-terminal nitrogen of Pro 2 from the opposite subunit provides the other ligand. A structural comparison of CooA in the absence of effector and DNA (off state) with that of CAP in the effector and DNA bound state (on state) leads to a plausible model for the mechanism of allosteric control in this class of proteins as well as the CO dependent activation of CooA.
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(as it appears on PubMed at http://www.pubmed.gov), where 11017196 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11017196}}
==About this Structure==
==About this Structure==
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[[Category: Catabolite gene activator protein]]
[[Category: Catabolite gene activator protein]]
[[Category: Heme sensor]]
[[Category: Heme sensor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:44:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:54:55 2008''

Revision as of 00:54, 1 July 2008

Image:1ft9.png

Template:STRUCTURE 1ft9

STRUCTURE OF THE REDUCED (FEII) CO-SENSING PROTEIN FROM R. RUBRUM

Template:ABSTRACT PUBMED 11017196

About this Structure

1FT9 is a Single protein structure of sequence from Rhodospirillum rubrum. Full crystallographic information is available from OCA.

Reference

Structure of the CO sensing transcription activator CooA., Lanzilotta WN, Schuller DJ, Thorsteinsson MV, Kerby RL, Roberts GP, Poulos TL, Nat Struct Biol. 2000 Oct;7(10):876-80. PMID:11017196

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