7ojn

==Lassa virus L protein in an elongation conformation [ELONGATION]==

<StructureSection load='7ojn' size='340' side='right'caption='[[7ojn]], [[Resolution|resolution]] 2.92&Aring;' scene=''>

<table><tr><td colspan='2'>[[7ojn]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_mammarenavirus Lassa mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OJN FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.92&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ojn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ojn OCA], [https://pdbe.org/7ojn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ojn RCSB], [https://www.ebi.ac.uk/pdbsum/7ojn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ojn ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/A0A3S8NV63_LASV A0A3S8NV63_LASV] RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate. During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.[HAMAP-Rule:MF_04086][PIRNR:PIRNR000836]

==See Also==

*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]

[[Category: Lassa mammarenavirus]]

[[Category: William H]]