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2c8n

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Current revision (14:09, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2c8n' size='340' side='right'caption='[[2c8n]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='2c8n' size='340' side='right'caption='[[2c8n]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2c8n]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"ruminiclostridium_thermocellum"_(viljoen_et_al._1926)_yutin_and_galperin_2013 "ruminiclostridium thermocellum" (viljoen et al. 1926) yutin and galperin 2013]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C8N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2c8n]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetivibrio_thermocellus Acetivibrio thermocellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C8N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=XYS:XYLOPYRANOSE'>XYS</scene>, <scene name='pdbligand=AHR:ALPHA-L-ARABINOFURANOSE'>AHR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c7f|2c7f]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHR:ALPHA-L-ARABINOFURANOSE'>AHR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=XYS:XYLOPYRANOSE'>XYS</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-reducing_end_alpha-L-arabinofuranosidase Non-reducing end alpha-L-arabinofuranosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.55 3.2.1.55] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8n OCA], [https://pdbe.org/2c8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c8n RCSB], [https://www.ebi.ac.uk/pdbsum/2c8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8n OCA], [https://pdbe.org/2c8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c8n RCSB], [https://www.ebi.ac.uk/pdbsum/2c8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8n ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IABF_ACET2 IABF_ACET2] Involved in the degradation of arabinan and is a key enzyme in the complete degradation of the plant cell wall. Catalyzes the cleavage of terminal alpha-(1->5)-arabinofuranosyl bonds in small oligosaccharides as alpha-(1->5)-linked arabinobiose/arabinotriose, but does not display significant activity against linear non-substituted arabinan. It is also highly efficient in the cleavage of alpha-(1->3)-linked arabinoside of xylobiose and of the alpha-(1->3)-linked arabinoside decorations of polymeric wheat arabinoxylan. It exhibits very low activity against sugar beet arabinan.<ref>PMID:16336192</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acetivibrio thermocellus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-reducing end alpha-L-arabinofuranosidase]]
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[[Category: D'Souza S]]
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[[Category: Davies, G J]]
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[[Category: Davies GJ]]
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[[Category: Gilbert, H J]]
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[[Category: Gilbert HJ]]
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[[Category: Smith, N L]]
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[[Category: Smith NL]]
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[[Category: Souza, S D]]
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[[Category: Taylor EJ]]
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[[Category: Taylor, E J]]
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[[Category: Turkenburg JP]]
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[[Category: Turkenburg, J P]]
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[[Category: Arabinan]]
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[[Category: Arabinofuranosidase]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Xylan]]
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Current revision

The Structure of a family 51 arabinofuranosidase, Araf51, from Clostridium thermocellum in complex with 1,3-linked arabinoside of xylobiose.

PDB ID 2c8n

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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