Fel d 1
From Proteopedia
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==1PUO - Fel d 1: The major cat allergen== | ==1PUO - Fel d 1: The major cat allergen== | ||
<StructureSection load='1puo' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1puo' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | The major allergen in cats, Fel d 1, belongs to the secretoglobin family of proteins and is, worldwide, one of the major causes of allergic asthma, as it induces IgE responses in 90 to 95% of those allergic to cats and in 60 to 90% of total allergenic activity to cat hair. Symptoms range from mild rhinitis and conjunctivitis to life-threatening asthmatic responses. The structure of Fel d 1 displays the location of three previously defined Fel d 1 IgE epitopes on the surface of the protein.<ref>KAISER, Liselotte; GRÖNLUND, Hans; SANDALOVA, Tatyana; LJUNGGREN, Hans-Gustaf; HAGE-HAMSTEN, Marianne van; ACHOUR, Adnane; SCHNEIDER, Gunter. The Crystal Structure of the Major Cat Allergen Fel d 1, a Member of the Secretoglobin Family. The Journal of Biological Chemistry, [s. l.], v. 278, n. 39, p. 37730–37735, 2003. doi: https://doi.org/10.1074/jbc.M304740200.</ref> | + | The major allergen in cats, Fel d 1, belongs to the secretoglobin family of proteins and is, worldwide, one of the major causes of allergic asthma, as it induces IgE responses in 90 to 95% of those allergic to cats and in 60 to 90% of total allergenic activity to cat hair. Symptoms range from mild rhinitis and conjunctivitis to life-threatening asthmatic responses. The structure of Fel d 1 displays the location of three previously defined Fel d 1 IgE epitopes on the surface of the protein.<ref name="[1]">KAISER, Liselotte; GRÖNLUND, Hans; SANDALOVA, Tatyana; LJUNGGREN, Hans-Gustaf; HAGE-HAMSTEN, Marianne van; ACHOUR, Adnane; SCHNEIDER, Gunter. The Crystal Structure of the Major Cat Allergen Fel d 1, a Member of the Secretoglobin Family. The Journal of Biological Chemistry, [s. l.], v. 278, n. 39, p. 37730–37735, 2003. doi: https://doi.org/10.1074/jbc.M304740200.</ref> |
| - | It is produced mainly by the salivary and sebaceous glands, it is also present in the perianal, lacrimal and squamous epithelial cells and is attached to the cat's hair through the habit of licking.<ref>WANDALSEN, Gustavo Falbo; SANO, Flavio; SOLÉ, Dirceu. Alérgenos do gato nas alergias respiratórias: situação atual e novas perspectivas. Asma, alergia e imunologia, São Paulo, SP, Brasil, v. 4, n. 1, p. 61-71, 10 mar. 2020. doi: http://dx.doi.org/10.5935/2526-5393.20200004.</ref> | + | It is produced mainly by the salivary and sebaceous glands, it is also present in the perianal, lacrimal and squamous epithelial cells and is attached to the cat's hair through the habit of licking.<ref name="[1]"/><ref>WANDALSEN, Gustavo Falbo; SANO, Flavio; SOLÉ, Dirceu. Alérgenos do gato nas alergias respiratórias: situação atual e novas perspectivas. Asma, alergia e imunologia, São Paulo, SP, Brasil, v. 4, n. 1, p. 61-71, 10 mar. 2020. doi: http://dx.doi.org/10.5935/2526-5393.20200004.</ref> |
== Function == | == Function == | ||
The biological function of Fel d 1 is still unknown, however it is thought to have a pheromone/chemical signaling function. | The biological function of Fel d 1 is still unknown, however it is thought to have a pheromone/chemical signaling function. | ||
Revision as of 23:32, 2 December 2021
1PUO - Fel d 1: The major cat allergen
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References
- ↑ 1.0 1.1 KAISER, Liselotte; GRÖNLUND, Hans; SANDALOVA, Tatyana; LJUNGGREN, Hans-Gustaf; HAGE-HAMSTEN, Marianne van; ACHOUR, Adnane; SCHNEIDER, Gunter. The Crystal Structure of the Major Cat Allergen Fel d 1, a Member of the Secretoglobin Family. The Journal of Biological Chemistry, [s. l.], v. 278, n. 39, p. 37730–37735, 2003. doi: https://doi.org/10.1074/jbc.M304740200.
- ↑ WANDALSEN, Gustavo Falbo; SANO, Flavio; SOLÉ, Dirceu. Alérgenos do gato nas alergias respiratórias: situação atual e novas perspectivas. Asma, alergia e imunologia, São Paulo, SP, Brasil, v. 4, n. 1, p. 61-71, 10 mar. 2020. doi: http://dx.doi.org/10.5935/2526-5393.20200004.
- ↑ https://doi.org/10.1016/j.jmb.2007.04.074
