Fel d 1
From Proteopedia
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Chain 1 has about 8kDa, composed of a residue of 70 amino acids and chain 2 has about 10 kDa, which can be composed of a residue of 90 amino acids, found preferably in the sebaceous glands, or composed of a residue of 92 amino acids, which is expressed by the salivary glands. Its glycan portion is found in chain 2 and the recombinant structure of Fel d 1 reveals that the N33 residue is located in the loop connecting the H2 and H3 helices and that the side chain is exposed to the solvent<ref name="[1]"/><ref name="[4]"/>. | Chain 1 has about 8kDa, composed of a residue of 70 amino acids and chain 2 has about 10 kDa, which can be composed of a residue of 90 amino acids, found preferably in the sebaceous glands, or composed of a residue of 92 amino acids, which is expressed by the salivary glands. Its glycan portion is found in chain 2 and the recombinant structure of Fel d 1 reveals that the N33 residue is located in the loop connecting the H2 and H3 helices and that the side chain is exposed to the solvent<ref name="[1]"/><ref name="[4]"/>. | ||
| - | Figure 1 shows the general structure of a Fel d 1 monomer, shown in two different orientations, rotated 90° around the vertical axis. Chains 1 and 2 correspond to the gold and blue helices respectively. The dotted line indicates the disordered loop (residues 75 to 92). The three disulfide bridges connecting chains 1 and 2 are shown in green. An arrow indicates the unique glycosylation site at residue N33. | + | Figure 1 shows the general structure of a Fel d 1 monomer, shown in two different orientations, rotated 90° around the vertical axis. Chains 1 and 2 correspond to the gold and blue helices respectively. The dotted line indicates the disordered loop (residues 75 to 92). The three disulfide bridges connecting chains 1 and 2 are shown in green. An arrow indicates the unique glycosylation site at residue N33<ref name="[1]"/>.[[Image:Monomero.png | thumb | '''Figure 1.'''General structure of a Fel d 1 monomer, shown in two distinct orientations, rotated 90° about the vertical axis.]] |
== '''References''' == | == '''References''' == | ||
<references/> | <references/> | ||
Revision as of 00:31, 3 December 2021
1PUO - Fel d 1: The major cat allergen
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