1fue

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[[Image:1fue.gif|left|200px]]
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{{Seed}}
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[[Image:1fue.png|left|200px]]
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{{STRUCTURE_1fue| PDB=1fue | SCENE= }}
{{STRUCTURE_1fue| PDB=1fue | SCENE= }}
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'''FLAVODOXIN FROM HELICOBACTER PYLORI'''
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===FLAVODOXIN FROM HELICOBACTER PYLORI===
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==Overview==
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The redox protein flavodoxin has been shown earlier to be reduced by the pyruvate-oxidoreductase (POR) enzyme complex of Helicobacter pylori, and also was proposed to be involved in the pathogenesis of gastric mucosa-associated lymphoid-tissue lymphoma (MALToma). Here, we report its X-ray structure, which is similar to flavodoxins of other bacteria and cyanobacteria. However, H. pylori flavodoxin has an alanine residue near the isoalloxazine ring of its cofactor flavin mononucleotide (FMN), while the other previously crystallized flavodoxins have a larger hydrophobic residue at this position. This creates a solute filled hole near the FMN cofactor of H. pylori flavodoxin. We also show that flavodoxin is essential for the survival of H. pylori, and conclude that its structure can be used as a starting point for the modeling of an inhibitor for the interaction between the POR-enzyme complex and flavodoxin.
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The line below this paragraph, {{ABSTRACT_PUBMED_11790835}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11790835 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11790835}}
==About this Structure==
==About this Structure==
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[[Category: Fmn]]
[[Category: Fmn]]
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:46:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:57:43 2008''

Revision as of 00:57, 1 July 2008

Image:1fue.png

Template:STRUCTURE 1fue

FLAVODOXIN FROM HELICOBACTER PYLORI

Template:ABSTRACT PUBMED 11790835

About this Structure

1FUE is a Single protein structure of sequence from Helicobacter pylori. Full crystallographic information is available from OCA.

Reference

Crystal structure of oxidized flavodoxin, an essential protein in Helicobacter pylori., Freigang J, Diederichs K, Schafer KP, Welte W, Paul R, Protein Sci. 2002 Feb;11(2):253-61. PMID:11790835

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