1fui

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[[Image:1fui.gif|left|200px]]
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{{Seed}}
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[[Image:1fui.png|left|200px]]
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{{STRUCTURE_1fui| PDB=1fui | SCENE= }}
{{STRUCTURE_1fui| PDB=1fui | SCENE= }}
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'''L-FUCOSE ISOMERASE FROM ESCHERICHIA COLI'''
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===L-FUCOSE ISOMERASE FROM ESCHERICHIA COLI===
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==Overview==
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The three-dimensional structure of L-fucose isomerase from Escherichia coli has been determined by X-ray crystallography at 2.5 A resolution. This ketol isomerase converts the aldose L-fucose into the corresponding ketose L-fuculose using Mn2+ as a cofactor. Being a hexamer with 64,976 Da per subunit, L-fucose isomerase is the largest structurally known ketol isomerase. The enzyme shows neither sequence nor structural similarity with other ketol isomerases. The hexamer obeys D3 symmetry and forms the crystallographic asymmetric unit. The strict and favorably oriented local symmetry allowed for a computational phase extension from 7.3 A to 2.5 A resolution. The structure was solved with an L-fucitol molecule bound to the catalytic center such that the hydroxyl groups at positions 1 and 2 are ligands of the manganese ion. Most likely, L-fucitol mimics a bound L-fucose molecule in its open chain form. The protein environment suggests strongly that the reaction belongs to the ene-diol type.
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The line below this paragraph, {{ABSTRACT_PUBMED_9367760}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9367760 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9367760}}
==About this Structure==
==About this Structure==
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[[Category: Ketol isomerase]]
[[Category: Ketol isomerase]]
[[Category: L-fucose to l-fuculose conversion]]
[[Category: L-fucose to l-fuculose conversion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:46:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:58:03 2008''

Revision as of 00:58, 1 July 2008

Image:1fui.png

Template:STRUCTURE 1fui

L-FUCOSE ISOMERASE FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 9367760

About this Structure

1FUI is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of L-fucose isomerase from Escherichia coli., Seemann JE, Schulz GE, J Mol Biol. 1997 Oct 17;273(1):256-68. PMID:9367760

Page seeded by OCA on Tue Jul 1 03:58:03 2008

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