1cx8
From Proteopedia
(New page: 200px<br /> <applet load="1cx8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cx8, resolution 3.2Å" /> '''CRYTAL STRUCTURE OF ...) |
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| - | [[Image:1cx8.gif|left|200px]]<br /> | + | [[Image:1cx8.gif|left|200px]]<br /><applet load="1cx8" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1cx8" size=" | + | |
caption="1cx8, resolution 3.2Å" /> | caption="1cx8, resolution 3.2Å" /> | ||
'''CRYTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR'''<br /> | '''CRYTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The transferrin receptor (TfR) undergoes multiple rounds of | + | The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome. The crystal structure of the dimeric ectodomain of the human TfR, determined here to 3.2 angstroms resolution, reveals a three-domain subunit. One domain closely resembles carboxy- and aminopeptidases, and features of membrane glutamate carboxypeptidase can be deduced from the TfR structure. A model is proposed for Tf binding to the receptor. |
==About this Structure== | ==About this Structure== | ||
| - | 1CX8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and SM as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1CX8 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb35_1.html Ferritin and Transferrin]]. Full crystallographic information is available from [http:// | + | 1CX8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=SM:'>SM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1CX8 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb35_1.html Ferritin and Transferrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Borhani, D.]] | [[Category: Borhani, D.]] | ||
[[Category: Galluser, R.]] | [[Category: Galluser, R.]] | ||
| - | [[Category: Harrison, S | + | [[Category: Harrison, S C.]] |
| - | [[Category: Lawrence, C | + | [[Category: Lawrence, C M.]] |
[[Category: Ray, S.]] | [[Category: Ray, S.]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: human transferrin receptor]] | [[Category: human transferrin receptor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:10:42 2008'' |
Revision as of 10:10, 21 February 2008
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CRYTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR
Overview
The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome. The crystal structure of the dimeric ectodomain of the human TfR, determined here to 3.2 angstroms resolution, reveals a three-domain subunit. One domain closely resembles carboxy- and aminopeptidases, and features of membrane glutamate carboxypeptidase can be deduced from the TfR structure. A model is proposed for Tf binding to the receptor.
About this Structure
1CX8 is a Single protein structure of sequence from Homo sapiens with and as ligands. The following page contains interesting information on the relation of 1CX8 with [Ferritin and Transferrin]. Full crystallographic information is available from OCA.
Reference
Crystal structure of the ectodomain of human transferrin receptor., Lawrence CM, Ray S, Babyonyshev M, Galluser R, Borhani DW, Harrison SC, Science. 1999 Oct 22;286(5440):779-82. PMID:10531064
Page seeded by OCA on Thu Feb 21 12:10:42 2008
