1ai8
From Proteopedia
(New page: 200px<br /> <applet load="1ai8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ai8, resolution 1.85Å" /> '''HUMAN ALPHA-THROMBI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AI8 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]] and [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with T42 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AI8 OCA]]. | + | 1AI8 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]] and [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with T42 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Thrombin Thrombin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Structure known Active Site: S1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AI8 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Thrombin]] | ||
[[Category: Deadman, J.]] | [[Category: Deadman, J.]] | ||
[[Category: Dodson, G.]] | [[Category: Dodson, G.]] | ||
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[[Category: hydrolase (serine proteinase)]] | [[Category: hydrolase (serine proteinase)]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:32:36 2007'' |
Revision as of 09:27, 30 October 2007
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HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG
Overview
Thrombin is a multifunctional serine proteinase that plays a key role in, coagulation while exhibiting several other key cellular bioregulatory, functions. The X-ray crystal structure of human alpha-thrombin was, determined in its complex with the specific thrombin inhibitor, D-Phe-Pro-Arg chloromethylketone (PPACK) using Patterson search methods, and a search model derived from trypsinlike proteinases of known spatial, structure (Bode, W., Mayr, I., Baumann, U., Huber, R., Stone, S.R., &, Hofsteenge, J., 1989, EMBO J. 8, 3467-3475). The crystallographic, refinement of the PPACK-thrombin model has now been completed at an R, value of 0.156 (8 to 1.92 A); in particular, the amino- and the, carboxy-termini of the thrombin A-chain are now defined and all side-chain, atoms localized; only ... [(full description)]
About this Structure
1AI8 is a [Protein complex] structure of sequences from [Hirudo medicinalis] and [Homo sapiens] with T42 as [ligand]. Active as [Thrombin], with EC number [3.4.21.5]. Structure known Active Site: S1. Full crystallographic information is available from [OCA].
Reference
The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships., Bode W, Turk D, Karshikov A, Protein Sci. 1992 Apr;1(4):426-71. PMID:1304349
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