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2cz3

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Current revision (11:32, 22 May 2024) (edit) (undo)
 
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<StructureSection load='2cz3' size='340' side='right'caption='[[2cz3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2cz3' size='340' side='right'caption='[[2cz3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2cz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CZ3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2cz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CZ3 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cz2|2cz2]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cz3 OCA], [https://pdbe.org/2cz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cz3 RCSB], [https://www.ebi.ac.uk/pdbsum/2cz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cz3 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cz3 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cz3 OCA], [https://pdbe.org/2cz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cz3 RCSB], [https://www.ebi.ac.uk/pdbsum/2cz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cz3 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cz3 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MAAI_MOUSE MAAI_MOUSE]] Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity).
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[https://www.uniprot.org/uniprot/MAAI_MOUSE MAAI_MOUSE] Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Kinoshita, Y]]
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[[Category: Kinoshita Y]]
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[[Category: Mizohata, E]]
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[[Category: Mizohata E]]
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[[Category: Morita, S]]
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[[Category: Morita S]]
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[[Category: Nagano, K]]
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[[Category: Nagano K]]
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[[Category: Structural genomic]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M]]
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[[Category: Uchikubo T]]
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[[Category: Uchikubo, T]]
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[[Category: Uda H]]
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[[Category: Uda, H]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Gst]]
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[[Category: Gstz1-1]]
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[[Category: Isomerase]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Transferase]]
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Current revision

Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from Mus musculus (form-2 crystal)

PDB ID 2cz3

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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