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2dno

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Current revision (18:45, 29 May 2024) (edit) (undo)
 
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==Solution structure of RNA binding domain in Trinucleotide repeat containing 4 variant==
==Solution structure of RNA binding domain in Trinucleotide repeat containing 4 variant==
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<StructureSection load='2dno' size='340' side='right'caption='[[2dno]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2dno' size='340' side='right'caption='[[2dno]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2dno]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2dno]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNO FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dno OCA], [https://pdbe.org/2dno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dno RCSB], [https://www.ebi.ac.uk/pdbsum/2dno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dno ProSAT], [https://www.topsan.org/Proteins/RSGI/2dno TOPSAN]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dno OCA], [https://pdbe.org/2dno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dno RCSB], [https://www.ebi.ac.uk/pdbsum/2dno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dno ProSAT], [https://www.topsan.org/Proteins/RSGI/2dno TOPSAN]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CELF3_HUMAN CELF3_HUMAN] RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.<ref>PMID:11158314</ref> <ref>PMID:15009664</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dno ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dno ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y]]
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[[Category: Muto Y]]
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[[Category: Structural genomic]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M]]
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[[Category: Terada T]]
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[[Category: Terada, T]]
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[[Category: Tsuda K]]
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[[Category: Tsuda, K]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rbd]]
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[[Category: Rna binding protein]]
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[[Category: Rrm domain]]
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[[Category: Rsgi]]
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Current revision

Solution structure of RNA binding domain in Trinucleotide repeat containing 4 variant

PDB ID 2dno

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