2yy9
From Proteopedia
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<StructureSection load='2yy9' size='340' side='right'caption='[[2yy9]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2yy9' size='340' side='right'caption='[[2yy9]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yy9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2yy9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YY9 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yy9 OCA], [https://pdbe.org/2yy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yy9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yy9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2yy9 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yy9 OCA], [https://pdbe.org/2yy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yy9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yy9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2yy9 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TZAP_MOUSE TZAP_MOUSE] Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.[UniProtKB:P10074] | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Kishishita | + | [[Category: Kishishita S]] |
| - | [[Category: Murayama | + | [[Category: Murayama K]] |
| - | [[Category: Nishino | + | [[Category: Nishino A]] |
| - | + | [[Category: Shirouzu M]] | |
| - | [[Category: Shirouzu | + | [[Category: Terada T]] |
| - | [[Category: Terada | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Crystal structure of BTB domain from mouse HKR3
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