1fw6

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[[Image:1fw6.gif|left|200px]]
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{{STRUCTURE_1fw6| PDB=1fw6 | SCENE= }}
{{STRUCTURE_1fw6| PDB=1fw6 | SCENE= }}
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'''CRYSTAL STRUCTURE OF A TAQ MUTS-DNA-ADP TERNARY COMPLEX'''
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===CRYSTAL STRUCTURE OF A TAQ MUTS-DNA-ADP TERNARY COMPLEX===
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==Overview==
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The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also possess a conserved ATPase activity that belongs to the ATP binding cassette (ABC) superfamily. Here we report the crystal structure of a ternary complex of MutS-DNA-ADP and assays of initiation of mismatch repair in conjunction with perturbation of the composite ATPase active site by mutagenesis. These studies indicate that MutS has to bind both ATP and the mismatch DNA simultaneously in order to activate the other mismatch repair proteins. We propose that the MutS ATPase activity plays a proofreading role in DNA mismatch repair, verification of mismatch recognition, and authorization of repair.
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(as it appears on PubMed at http://www.pubmed.gov), where 11172706 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11172706}}
==About this Structure==
==About this Structure==
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[[Category: Multi-domain structure]]
[[Category: Multi-domain structure]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:02:12 2008''

Revision as of 01:02, 1 July 2008

Image:1fw6.png

Template:STRUCTURE 1fw6

CRYSTAL STRUCTURE OF A TAQ MUTS-DNA-ADP TERNARY COMPLEX

Template:ABSTRACT PUBMED 11172706

About this Structure

1FW6 is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair., Junop MS, Obmolova G, Rausch K, Hsieh P, Yang W, Mol Cell. 2001 Jan;7(1):1-12. PMID:11172706

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