2aiy
From Proteopedia
(New page: 200px<br /> <applet load="2aiy" size="450" color="white" frame="true" align="right" spinBox="true" caption="2aiy" /> '''R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2AIY is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/ ]] with IPH as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2AIY OCA]]. | + | 2AIY is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/ ]] with IPH as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: ZN1 and ZN2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2AIY OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: hormone]] | [[Category: hormone]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:32:39 2007'' |
Revision as of 09:27, 30 October 2007
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R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 20 STRUCTURES
Overview
Crystallographic and NMR studies of insulin have revealed a highly, flexible molecule with a range of different aggregation and structural, states; the importance of these states for the function of the hormone is, still unclear. To address this question, we have studied the solution, structure of the insulin R6 symmetric hexamer using NMR spectroscopy., Structure determination of symmetric oligomers by NMR is complicated due, to 'symmetry ambiguity' between intra- and intermonomer NOEs, and between, different classes of intermonomer NOEs. Hence, to date, only two symmetric, tetramers and one symmetric pentamer (VTB, B subunit of verotoxin) have, been solved by NMR: there has been no other symmetric hexamer or, higher-order oligomer. Recently, we reported a solution structure for R6, ... [(full description)]
About this Structure
2AIY is a [Protein complex] structure of sequences from [[1]] with IPH as [ligand]. Structure known Active Sites: ZN1 and ZN2. Full crystallographic information is available from [OCA].
Reference
Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure., O'Donoghue SI, Chang X, Abseher R, Nilges M, Led JJ, J Biomol NMR. 2000 Feb;16(2):93-108. PMID:10723989
Page seeded by OCA on Tue Oct 30 11:32:39 2007
